US 12,226,495 B2
18F-labeled novel tetrazines imaging probes for pretargeting in PET imaging
Andreas Kjær, Copenhagen Ø (DK); Matthias Manfred Herth, Copenhagen Ø (DK); Elsa Johanna Louise Steen, Copenhagen Ø (DK); Jesper Tranekær Jørgensen, Copenhagen Ø (DK); Hannes Mikula, Vienna (AT); and Christoph Denk, Vienna (AT)
Assigned to Rigshospitalet, Copenhagen Ø (DK); and Københavns Universitet, Copenhagen Ø (DK)
Appl. No. 17/612,144
Filed by Rigshospitalet, Copenhagen Ø (DK); and Københavns Universitet, Copenhagen Ø (DK)
PCT Filed May 25, 2020, PCT No. PCT/EP2020/064432
§ 371(c)(1), (2) Date Nov. 17, 2021,
PCT Pub. No. WO2020/239687, PCT Pub. Date Dec. 3, 2020.
Claims priority of application No. PA201900639 (DK), filed on May 24, 2019.
Prior Publication US 2022/0249709 A1, Aug. 11, 2022
Int. Cl. A61K 51/04 (2006.01); A61P 35/00 (2006.01); C07D 257/08 (2006.01); C07D 401/04 (2006.01)
CPC A61K 51/0455 (2013.01) [A61K 51/044 (2013.01); A61K 51/0491 (2013.01); A61P 35/00 (2018.01); C07D 257/08 (2013.01); C07D 401/04 (2013.01); C07B 2200/05 (2013.01)] 10 Claims
 
1. A 18F-labelled tetrazine formed by reacting a tetrazine with a 18F-labelled azide synthon, in which
said tetrazine is a compound according to any of structures 1-6:

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
and
said 18F-labelled azide synthon is a compound according to structures [18F]c:

OG Complex Work Unit Chemistry