US 12,226,491 B2
Nano-satellite complexes
Duxin Sun, Ann Arbor, MI (US); Ryan Clauson, Ann Arbor, MI (US); Hongwei Chen, Ann Arbor, MI (US); Chengyi Li, Ann Arbor, MI (US); Wei Gao, Ann Arbor, MI (US); Luke Bugada, Ann Arbor, MI (US); Fei Wen, Ann Arbor, MI (US); Brett Hill, Ann Arbor, MI (US); and Syed Monem Rizvi, Ann Arbor, MI (US)
Assigned to The Regents of the University of Michigan, Ann Arbor, MI (US)
Filed by The Regents of the University of Michigan, Ann Arbor, MI (US)
Filed on Apr. 16, 2021, as Appl. No. 17/232,751.
Application 17/232,751 is a continuation in part of application No. PCT/US2019/056765, filed on Oct. 17, 2019.
Claims priority of provisional application 62/746,755, filed on Oct. 17, 2018.
Prior Publication US 2021/0346478 A1, Nov. 11, 2021
Int. Cl. A61K 47/69 (2017.01); A61K 9/16 (2006.01); A61K 38/19 (2006.01); A61K 39/00 (2006.01); A61K 39/295 (2006.01); A61K 39/39 (2006.01); A61K 45/06 (2006.01); A61K 47/02 (2006.01); A61K 47/64 (2017.01); A61P 35/00 (2006.01)
CPC A61K 47/6929 (2017.08) [A61K 9/167 (2013.01); A61K 38/191 (2013.01); A61K 39/0011 (2013.01); A61K 39/001106 (2018.08); A61K 39/295 (2013.01); A61K 39/39 (2013.01); A61K 39/4611 (2023.05); A61K 39/4612 (2023.05); A61K 39/4622 (2023.05); A61K 39/464406 (2023.05); A61K 45/06 (2013.01); A61K 47/02 (2013.01); A61K 47/646 (2017.08); A61P 35/00 (2018.01); A61K 2039/60 (2013.01); A61K 2039/627 (2013.01); A61K 2039/64 (2013.01); A61K 2239/49 (2023.05)] 9 Claims
 
1. A composition comprising: a nano-satellite complex, wherein said nano-satellite complex surface has a negative charge, and wherein said nano-satellite complex comprises:
a) a core nanoparticle complex comprising a biocompatible coating surrounding a nanoparticle core;
b) 10-20 gold satellite particles attached to, or absorbed to, said biocompatible coating;
c) a plurality of antigenic peptides conjugated to, or absorbed to, said satellite particles; and
d) wherein said nano-satellite complex comprises all of the following properties:
i) wherein the weight-to-weight ratio of all of said satellite particles to said nanoparticle core is 10-40%;
ii) wherein the diameter of each of said satellite particles is 1-5 nm, and the diameter of the nano-satellite complex is 20-70 nm;
iii) wherein said plurality of antigenic peptides is 1500-2500 antigenic peptides;
iv) wherein 100-225 of said plurality of said antigenic peptides are present on each of said satellite particles; and
v) wherein the average distance between each of said satellite particles is 4-7 nm.