	US 12,226,474 B2
	Methods and compositions for treating infections
Barbara L. Hibner, Winchester, MA (US)
Assigned to Decoy Therapeutics Inc., Cambridge, MA (US)
Filed by Decoy Therapeutics Inc., Cambridge, MA (US)
Filed on Jan. 18, 2022, as Appl. No. 17/577,681.
Claims priority of provisional application 63/140,387, filed on Jan. 22, 2021.
Prior Publication US 2022/0233683 A1, Jul. 28, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/215 (2006.01); A61K 39/00 (2006.01)

CPC A61K 39/215 (2013.01) [A61K 2039/6018 (2013.01); A61K 2039/627 (2013.01)]

7 Claims

1. A compound having the formula:

(Peptide-Linker)_n-B-Hydrophobic Moiety

wherein said Peptide is a non-native C-terminus heptad repeat region (HRC) Peptide that comprises the sequence of:

	(SEQ ID NO. 2)
	dIdGdSdIdD NASVVNIQKEIDRLNEVAKNLNESLIDLQEL,

wherein the dIdGdSdIdD represents that the first five amino acids of said sequence are in the D-configuration;

said Linker is a bivalent linking moiety,

B is a multivalent moiety and n is an integer selected from 1, 2, and 3.