US 12,226,471 B2
Nucleoside-modified mRNA-lipid nanoparticle lineage vaccine for hepatitis C virus
Drew Weissman, Wynnewood, PA (US); George M. Shaw, Wallingford, PA (US); Justin R. Bailey, Timonium, MD (US); Stuart C. Ray, Lutherville, MD (US); James Crowe, Jr., Nashville, TN (US); and Andrew Flyak, Pasadena, CA (US)
Assigned to The Trustees of the University of Pennsylvania, Philadelphia, PA (US); The Johns Hopkins University, Baltimore, MD (US); and Vanderbilt University, Nashville, TN (US)
Filed by The Trustees of the University of Pennsylvania, Philadelphia, PA (US); The Johns Hopkins University, Baltimore, MD (US); and Vanderbilt University, Nashville, TN (US)
Filed on May 1, 2023, as Appl. No. 18/310,066.
Application 18/310,066 is a continuation of application No. 16/608,392, granted, now 11,660,332, previously published as PCT/US2018/029686, filed on Apr. 27, 2018.
Claims priority of provisional application 62/490,828, filed on Apr. 27, 2017.
Prior Publication US 2024/0123050 A1, Apr. 18, 2024
Int. Cl. A61K 48/00 (2006.01); A61K 9/127 (2006.01); A61K 39/12 (2006.01); A61K 39/29 (2006.01); A61K 39/39 (2006.01); A61P 31/14 (2006.01); A61K 9/00 (2006.01); A61K 39/00 (2006.01)
CPC A61K 39/12 (2013.01) [A61K 9/127 (2013.01); A61K 39/29 (2013.01); A61K 39/39 (2013.01); A61P 31/14 (2018.01); A61K 9/0019 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/53 (2013.01); A61K 2039/55555 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A lineage vaccine for inducing an immune response against Hepatitis C virus (HCV) in a subject comprising a combination of isolated nucleoside-modified RNA molecules, wherein the combination of isolated nucleoside-modified RNA molecules encodes a combination of sequential lineage antigens for inducing an immune response against Hepatitis C virus (HCV) in a subject, wherein the combination of isolated nucleoside-modified RNA molecules comprises at least one isolated nucleoside-modified RNA molecule encoding each of the HCV antigens as set forth in SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 13, SEQ ID NO: 14, SEQ ID NO: 15, SEQ ID NO: 16, SEQ ID NO: 17, and SEQ ID NO: 18.