	US 12,226,449 B2
	Materials and methods for the prevention of rheumatoid arthritis
Ritu Chakravarti, Toledo, OH (US); and Bina Joe, Toledo, OH (US)
Assigned to The University of Toledo, Toledo, OH (US)
Appl. No. 17/294,091
Filed by The University of Toledo, Toledo, OH (US)
PCT Filed Nov. 15, 2019, PCT No. PCT/US2019/061605 § 371(c)(1), (2) Date May 14, 2021, PCT Pub. No. WO2020/102623, PCT Pub. Date May 22, 2020.
Claims priority of provisional application 62/767,898, filed on Nov. 15, 2018.
Prior Publication US 2022/0008503 A1, Jan. 13, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/17 (2006.01); A61K 45/06 (2006.01); A61P 29/00 (2006.01)

CPC A61K 38/17 (2013.01) [A61K 45/06 (2013.01); A61P 29/00 (2018.01)]

13 Claims

1. A method for preventing, treating, or delaying the onset of rheumatoid arthritis, the method comprising:

administering an effective amount of 14-3-3ζ, or a variant thereof having C terminus 63 residues conserved with human 14-3-3ζ, to a subject at risk for developing rheumatoid arthritis, and preventing, treating, or delaying the onset of rheumatoid arthritis in the subject.