US 12,226,441 B2
Composition for inhibiting intestinal permeability, treating leaky gut related diseases and/or preventing leaky gut related diseases
I-Hong Pan, Zhubei (TW); Kuei-Chang Li, Taipei (TW); Zong-Keng Kuo, Hsinchu (TW); Chu-Hsun Lu, Kaohsiung (TW); Yen-Wu Hsieh, Zhudong Township (TW); and Shu-Fang Wen, Baoshan Township (TW)
Assigned to INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, Hsinchu (TW)
Filed by INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, Hsinchu (TW)
Filed on Jun. 1, 2023, as Appl. No. 18/327,583.
Application 18/327,583 is a division of application No. 17/138,610, filed on Dec. 30, 2020, granted, now 11,701,399.
Claims priority of provisional application 62/981,720, filed on Feb. 26, 2020.
Claims priority of application No. 109146258 (TW), filed on Dec. 25, 2020.
Prior Publication US 2024/0165181 A1, May 23, 2024
Int. Cl. A61K 36/074 (2006.01); A61K 31/575 (2006.01); A61K 36/185 (2006.01); A61K 36/725 (2006.01); A61K 36/77 (2006.01); A61P 1/00 (2006.01); A61P 25/20 (2006.01); A61P 25/28 (2006.01)
CPC A61K 36/074 (2013.01) [A61K 31/575 (2013.01); A61K 36/185 (2013.01); A61K 36/725 (2013.01); A61K 36/77 (2013.01); A61P 1/00 (2018.01); A61P 25/20 (2018.01); A61P 25/28 (2018.01)] 14 Claims
 
1. A composition for inhibiting intestinal permeability, treating leaky gut related diseases and/or preventing leaky gut related diseases, comprising:
a herbal compound material or a herbal compound extract,
wherein the herbal compound material consists of:
Ganoderma;
red jujube;
longan; and
lotus seed,
wherein in the herbal compound material, a weight ratio of Ganoderma, red jujube, longan and lotus seed is 0.1-15:0.6-2:0.6-2:0.6-5, and
wherein the herbal compound extract consists of:
Ganoderma extract;
red jujube extract;
longan extract; and
lotus seed extract,
wherein a weight ratio of Ganoderma, red jujube, longan and lotus seed as preparation raw materials which are respectively needed to obtain the Ganoderma extract, the red jujube extract, the longan extract and the lotus seed extract contained in the herbal compound extract is 0.1-15:0.6-2:0.6-2:0.6-5, and
wherein the herbal compound material or herbal compound extract is capable of inhibiting intestinal permeability, treating leaky gut related diseases and/or preventing leaky gut related diseases,
wherein the leaky gut related diseases comprise inflammatory bowel disease, celiac disease, irritable bowel syndrome, acute pancreatitis, non-alcoholic steatohepatitis, alcoholic cirrhosis, type 1 diabetes, type 2 diabetes, obesity, chronic kidney disease, cardiovascular disease, multiple organ failure syndrome, AIDS, asthma, eczema, psoriasis, autism, depression, anxiety, schizophrenia, bipolar disorder, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, ankylosing spondylitis, fibromyalgia, chronic sleep fragmentation or insomnia.