US 12,226,438 B2
System and method for therapeutic compositions from a plurality of different birth tissues and exosomes
Terrell Suddarth, New Market, AL (US); Amanda Drobnis, Norton, MA (US); Bruce Werber, Fort Lauderdale, FL (US); and David Dutton, Comfort, TX (US)
Assigned to Hilltop BioSciences, Inc., Mansfield, MA (US)
Filed by Hilltop BioSciences, Inc., Mansfield, MA (US)
Filed on Jun. 6, 2022, as Appl. No. 17/832,997.
Claims priority of provisional application 63/212,525, filed on Jun. 18, 2021.
Prior Publication US 2022/0401496 A1, Dec. 22, 2022
Int. Cl. A61K 35/50 (2015.01); A61K 35/51 (2015.01)
CPC A61K 35/50 (2013.01) [A61K 35/51 (2013.01)] 41 Claims
 
1. A method for making a therapeutic composition from a plurality of different birth tissues from at least one mammalian donor, comprising:
receiving a first birth tissue;
processing the first birth tissue to isolate first subcellular elements from the first birth tissue;
evaluating the isolated first subcellular elements to determine at least a first concentration of at least one first constituent;
receiving a second birth tissue;
processing the second birth tissue to isolate second subcellular elements;
evaluating the isolated second subcellular elements to determine at least a second concentration of at least one second constituent; and
mixing at least a portion of the isolated first subcellular elements and at least a portion of the isolated second subcellular elements to provide an initial blend of isolated subcellular elements having a predetermined ratio of the at least one first constituent and the at least one second constituent in the initial blend of isolated subcellular elements providing the therapeutic composition;
wherein each birth tissue is different and selected from the group consisting of: amnion, allantois, allantoamnion, umbilical cord, Wharton's jelly, amniotic fluid, umbilical cord blood, umbilical cord blood extracts, and spongey layer.