US 12,226,421 B2
Nefopam dosage forms and methods of treatment
Shahin Fatholahi, Malvern, PA (US)
Filed by Shahin Fatholahi, Malvern, PA (US)
Filed on Jul. 19, 2023, as Appl. No. 18/223,581.
Application 18/223,581 is a continuation of application No. 17/322,098, filed on May 17, 2021, abandoned.
Application 17/322,098 is a continuation of application No. 16/912,324, filed on Jun. 25, 2020, granted, now 11,013,747, issued on May 25, 2021.
Application 16/912,324 is a continuation of application No. 15/699,856, filed on Sep. 8, 2017, granted, now 10,736,905, issued on Aug. 11, 2020.
Claims priority of provisional application 62/464,218, filed on Feb. 27, 2017.
Claims priority of provisional application 62/463,355, filed on Feb. 24, 2017.
Claims priority of provisional application 62/385,675, filed on Sep. 9, 2016.
Prior Publication US 2023/0364108 A1, Nov. 16, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/485 (2006.01); A61K 9/20 (2006.01); A61K 31/19 (2006.01); A61K 31/194 (2006.01); A61K 31/395 (2006.01); A61K 47/26 (2006.01); A61K 47/32 (2006.01); C07D 267/22 (2006.01)
CPC A61K 31/5545 (2017.08) [A61K 31/194 (2013.01); A61K 47/26 (2013.01); A61K 47/32 (2013.01); C07D 267/22 (2013.01)] 8 Claims
 
1. A method of treating pain in a patient comprising administering to the patient a pharmaceutical tablet comprising a homogenous matrix that comprises nefopam, nefopam metabolite, nefopam prodrug, isomer thereof or combinations of the foregoing, a carboxylic acid, and a modified release material wherein the tablet further comprises an opioid analgesic, NSAID, or combination thereof wherein the dose of opioid analgesic, NSAID, or combination thereof is about 50-70% of a normal dose.