	US 12,226,410 B2
	Methods for enhancing cellular clearance of pathological molecules via activation of the cellular protein ykt6
Joseph R. Mazzulli, Chicago, IL (US); and Leah K. Cuddy, Chicago, IL (US)
Assigned to Northwestern University, Evanston, IL (US)
Filed by NORTHWESTERN UNIVERSITY, Evanston, IL (US)
Filed on Oct. 19, 2020, as Appl. No. 17/073,603.
Claims priority of provisional application 62/923,159, filed on Oct. 18, 2019.
Prior Publication US 2021/0113552 A1, Apr. 22, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/4709 (2006.01); A61K 31/454 (2006.01); A61P 25/16 (2006.01); G01N 33/68 (2006.01)

CPC A61K 31/4709 (2013.01) [A61K 31/454 (2013.01); A61P 25/16 (2018.01); G01N 33/6896 (2013.01)]

10 Claims

1. A method for treating a disease or disorder associated with proteinopathy or cellular storage in a subject in need thereof, the method comprising administering to the subject an effective amount of a therapeutic agent that activates or augments activity of ykt6, wherein the therapeutic agent comprises a compound selected from the following compounds or a pharmaceutically acceptable salt thereof: