US 12,226,404 B2
Methods for making compositions for pulmonary administration
Robert O. Williams, III, Austin, TX (US); Keith P. Johnston, Austin, TX (US); Prapasri Sinswat, Austin, TX (US); Jason T. McConville, Austin, TX (US); Robert Talbert, San Antonio, TX (US); Jay I. Peters, San Antonio, TX (US); Alan B. Watts, Austin, TX (US); and True L. Rogers, Midland, MI (US)
Assigned to BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US)
Filed by Board of Regents, the University of Texas System, Austin, TX (US)
Filed on Jun. 9, 2022, as Appl. No. 17/836,067.
Application 17/836,067 is a continuation of application No. 16/294,885, filed on Mar. 6, 2019, granted, now 11,382,899.
Application 16/294,885 is a continuation of application No. 14/621,337, filed on Feb. 12, 2015, granted, now 10,231,955, issued on Mar. 19, 2019.
Application 14/621,337 is a continuation of application No. 12/522,774, granted, now 9,044,391, issued on Jun. 2, 2015, previously published as PCT/US2008/050795, filed on Jan. 10, 2008.
Claims priority of provisional application 60/884,383, filed on Jan. 10, 2007.
Prior Publication US 2023/0040283 A1, Feb. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/436 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 9/19 (2006.01); A61K 9/51 (2006.01); A61K 38/13 (2006.01); A61P 11/00 (2006.01); A61P 37/00 (2006.01); A61P 37/06 (2006.01)
CPC A61K 31/436 (2013.01) [A61K 9/0075 (2013.01); A61K 9/0078 (2013.01); A61K 9/1623 (2013.01); A61K 9/1694 (2013.01); A61K 9/19 (2013.01); A61K 9/5161 (2013.01); A61K 9/5192 (2013.01); A61K 38/13 (2013.01)] 9 Claims
 
1. A method of making a pharmaceutical powder, the powder comprising porous, nanostructured aggregates comprising tacrolimus and a carbohydrate, the nanostructured aggregates being composed of branched and interconnected nanorods, wherein the powder is a) free of cyclosporine, b) free of surfactants and c) free of ethanol, propylene glycol and polyethylene glycol, wherein the method comprises:
i) mixing tacrolimus and carbohydrate with a solvent;
ii) ultra-rapid freezing the mixture; and
iii) removing the solvent to provide the pharmaceutical powder.