US 12,226,380 B2
Method of regulating immunity in the intestines
Peihua Jiang, Clarksville, MD (US); and Weiwei Lei, Berwyn, PA (US)
Filed by Monell Chemical Senses Center, Philadelphia, PA (US)
Filed on Mar. 17, 2022, as Appl. No. 17/697,089.
Application 17/697,089 is a division of application No. 16/330,595, granted, now 11,278,507, previously published as PCT/US2017/047783, filed on Aug. 21, 2017.
Claims priority of provisional application 62/383,662, filed on Sep. 6, 2016.
Prior Publication US 2022/0313637 A1, Oct. 6, 2022
Int. Cl. A61K 31/194 (2006.01)
CPC A61K 31/194 (2013.01) 8 Claims
 
1. A method comprising administering to a mammalian subject at risk for, or having, an infection a composition or compound that stimulates the G protein receptor (GPR91) pathway in intestinal cells to release IL-25 and enhance a type II immune response in the subject, wherein the composition or compound is succinate or an analog thereof, and wherein the infection is prevented and/or treated in the mammalian subject.
 
7. A method comprising administering to a mammalian subject who is obese a composition or compound that stimulates the G protein receptor (GPR91) pathway in intestinal cells to release IL-25 and enhance a type II immune response in the subject, wherein the composition or compound is succinate or an analog thereof, and wherein the obesity is treated in the mammalian subject.