US 12,226,378 B2
Topical substance for vaginal use
Wendy Strgar, Eugene, OR (US)
Assigned to VAGINAL BIOME SCIENCE, INC., Eugene, OR (US)
Filed by VAGINAL BIOME SCIENCE, INC., Eugene, OR (US)
Filed on Oct. 26, 2022, as Appl. No. 18/049,983.
Application 18/049,983 is a continuation of application No. 17/209,252, filed on Mar. 23, 2021, granted, now 11,806,325.
Application 17/209,252 is a continuation of application No. 16/191,292, filed on Nov. 14, 2018, granted, now 10,952,979, issued on Mar. 23, 2021.
Application 16/191,292 is a continuation in part of application No. 15/691,645, filed on Aug. 30, 2017, granted, now 10,195,169, issued on Feb. 5, 2019.
Application 15/691,645 is a continuation in part of application No. 15/294,340, filed on Oct. 14, 2016, abandoned.
Application 15/294,340 is a continuation of application No. 14/636,035, filed on Mar. 2, 2015, granted, now 9,470,676, issued on Oct. 18, 2016.
Claims priority of provisional application 62/094,769, filed on Dec. 19, 2014.
Prior Publication US 2023/0070915 A1, Mar. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/191 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 47/02 (2006.01); A61K 47/12 (2006.01); A61K 47/36 (2006.01); A61K 47/38 (2006.01); G01N 33/50 (2006.01)
CPC A61K 31/191 (2013.01) [A61K 9/00 (2013.01); A61K 9/0034 (2013.01); A61K 9/06 (2013.01); A61K 47/02 (2013.01); A61K 47/12 (2013.01); A61K 47/36 (2013.01); A61K 47/38 (2013.01); G01N 33/50 (2013.01)] 22 Claims
 
1. A topical substance for vaginal use, the topical substance comprising:
a solvent;
a viscosity modifier;
at least one salt; and
from 0.2 to 2% by weight of lactic acid which is a mixture of a D-lactic acid and a L-lactic acid,
wherein the topical substance has an osmolality from 100 mOsm/Kg to 500 mOsm/Kg and a pH from 3.0 to 6.0.