	US 12,226,348 B2
	System and method of corneal cross-linking
Johannes Loerner, Roßtal (DE); Peter Riedel, Nuremberg (DE); and Linda Weise, Erlangen (DE)
Assigned to ALCON INC., Fribourg (CH)
Filed by ALCON INC., Fribourg (CH)
Filed on Dec. 14, 2020, as Appl. No. 17/120,842.
Claims priority of provisional application 62/947,772, filed on Dec. 13, 2019.
Prior Publication US 2021/0177651 A1, Jun. 17, 2021
Int. Cl. A61F 9/008 (2006.01)

CPC A61F 9/0084 (2013.01) [A61F 9/00836 (2013.01); A61F 2009/00846 (2013.01); A61F 2009/00848 (2013.01); A61F 2009/00853 (2013.01); A61F 2009/00872 (2013.01); A61F 2009/00893 (2013.01)]

19 Claims

1. A medical system, comprising:

at least one processor;

a camera configured to generate image data for an image of an eye of a patient;

a laser that is communicatively coupled to the at least one processor and that is configured to produce one or more laser beams along a Z-axis;

at least one lens;

at least one mirror; and

a memory medium that is coupled to the at least one processor and that includes instructions that, when executed by the at least one processor, cause the medical system to:

receive data and a plurality of intensity profiles associated with a plurality of locations of a cornea of the eye of the patient, the locations comprising a first location and a second location different from the first location, the first location associated with a first intensity profile, the second location associated with a second intensity profile, the first intensity profile providing a greater optical intensity than the second intensity profile to enhance a corneal cross-linking (CXL) effect, the data comprising for each of the plurality of locations: coordinate information, diameter information, period of time information, and pulse duration information;

adjust the at least one lens, based at least on the diameter information of the data associated with at least one location to set a diameter of a laser beam; and

perform, for each location of the plurality of locations, according to at least the data and the intensity profile for the location:

determine if the eye has changed from a first position of the eye to a second position of the eye, different from the first position of the eye;

performing at least one of:

if the eye has not changed from the first position of the eye to the second position of the eye, adjust the at least one mirror according to at least the data for the location;

if the eye has changed from the first position of the eye to the second position of the eye, adjust the at least one mirror according to at least the data for the location and the second position of the eye, the data for the location comprising coordinate information, wherein the coordinate information comprises an X-axis, a Y-axis, the Z-axis, an angle θ_Xmeasured from the Z-axis to the X-axis, an angle θ_Ymeasured from the Z-axis to the Y-axis, and a rotation angle ϕ measuring rotation about the Z-axis;

produce the laser beam;

direct the laser beam to the location according to the intensity profile and the period of time information associated with the location; and

identify an eye dropper in the image of the eye according to a pattern marking the eye dropper, the pattern comprising a fractal pattern that identifies the eye dropper, the eye dropper configured to dispense riboflavin onto the cornea to enhance the CXL effect.