US 12,226,250 B2
Multiple modality body composition analysis
Kevin E. Wilson, Marlborough, MA (US); John A. Shepherd, Oakland, CA (US); Bennett K. Ng, Oakland, CA (US); Mark Guetersloh, Marlborough, CA (US); Chao Huang, Marlborough, MA (US); Thomas L. Kelly, Marlborough, MA (US); Wei Wang, Marlborough, MA (US); and Howard Weiss, Marlborough, MA (US)
Assigned to Hologic, Inc., Marlborough, MA (US); and The Regents of the University of California, Oakland, CA (US)
Appl. No. 16/498,631
Filed by HOLOGIC, INC., Marlborough, MA (US); and THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
PCT Filed Mar. 22, 2018, PCT No. PCT/US2018/023817
§ 371(c)(1), (2) Date Sep. 27, 2019,
PCT Pub. No. WO2018/183086, PCT Pub. Date Oct. 4, 2018.
Claims priority of provisional application 62/480,017, filed on Mar. 31, 2017.
Prior Publication US 2020/0029927 A1, Jan. 30, 2020
Int. Cl. A61B 6/00 (2024.01); A61B 5/00 (2006.01); A61B 5/107 (2006.01); A61B 6/04 (2006.01); A61B 6/50 (2024.01); G01G 19/44 (2006.01)
CPC A61B 6/5247 (2013.01) [A61B 5/0064 (2013.01); A61B 5/0077 (2013.01); A61B 5/1075 (2013.01); A61B 5/1079 (2013.01); A61B 5/4872 (2013.01); A61B 5/4875 (2013.01); A61B 6/0407 (2013.01); A61B 6/4452 (2013.01); A61B 6/482 (2013.01); A61B 6/505 (2013.01); G01G 19/445 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A system comprising:
a support structure configured to move along an axis of a scanning target;
a dual-energy x-ray source mounted to the support structure, the dual energy x-ray source configured to emit dual-energy x-rays towards the scanning target along a scan path;
an x-ray detector configured to detect the dual-energy x-rays emitted from the dual-energy x-ray source after passing through the scanning target;
a first 3D optical imaging device mounted to the support structure and configured to obtain a first 3D optical image of a first side of the scanning target along the scan path; and
a second 3D optical imaging device mounted to the support structure and configured to concurrently obtain a second 3D optical image of a second side of the scanning target, the second side being opposite the first side with respect to the scanning target; and
a processing device communicatively coupled to the x-ray detector and the first 3D optical imaging device;
wherein at least the first 3D optical imaging device and the second 3D optical imaging device are fixed in place with respect to the scanning target to capture surfaces of the scanning target to form a 3D model of the scanning target; and
the processing device is configured to determine, on a per-pixel basis, amounts of at least three of: bone, fat tissue, lean tissue, dehydrated lean tissue, and water.