US 12,226,200 B2
Method for diagnosing gastro esophageal reflux disease
Haruhiro Inoue, Tokyo (JP)
Assigned to OLYMPUS CORPORATION, Tokyo (JP)
Filed by OLYMPUS CORPORATION, Tokyo (JP); and Haruhiro Inoue, Tokyo (JP)
Filed on May 30, 2019, as Appl. No. 16/426,713.
Prior Publication US 2020/0375485 A1, Dec. 3, 2020
Int. Cl. A61B 5/03 (2006.01); A61B 1/015 (2006.01); A61B 1/273 (2006.01)
CPC A61B 5/037 (2013.01) [A61B 1/015 (2013.01); A61B 1/2736 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A method for diagnosing gastro esophageal reflux disease (GERD), comprising:
identifying a threshold value of an internal pressure within a stomach of a person without GERD;
obtaining a first waveform of time-series change of the internal pressure within the stomach of the person without GERD, wherein the first waveform of time-series change increases to the threshold value when gas is supplied into the stomach;
obtaining a second waveform of time-series change of an internal pressure within a stomach of a person with GERD, wherein the second waveform of time-series change repeatedly increases and decreases within a pressure range when gas is supplied into the stomach and the second waveform of time-series change is flatter than the first waveform of time-series change;
inserting an endoscope into a stomach of a subject;
supplying a volume of gas substantially identical to a volume of gas which causes a person without GERD to have a body reflex of a closing cardia;
measuring an internal pressure only within the stomach of the subject while supplying gas into the stomach of the subject using the endoscope to obtain a waveform of time-series change of the internal pressure value of the subject, the internal pressure including a maximum value of the internal pressure in the stomach of the subject;
obtaining a third waveform of time-series change of the internal pressure value in the stomach of the subject;
comparing the maximum value of the subject to the threshold value of the person without GERD;
comparing the third waveform of time-series change to the first waveform of time-series change;
comparing the third waveform of time-series change to the second waveform of time-series change;
determining whether the subject has GERD based on the comparison of the maximum value of the subject to the threshold value of the person without GERD, the comparison of the third waveform of time-series change to the first waveform time-series change, and the comparison of the third waveform of time-series change to the second waveform of the time-series change.