US 12,226,194 B2
Method, apparatus and system for evaluating cardiac diastolic function
Lingjun Zeng, Shenzhen (CN); Zhengpei Chu, Shenzhen (CN); Pengbo Liu, Shenzhen (CN); and Shaochun Zhuang, Shenzhen (CN)
Assigned to CARDIOSTORY INC., Lewes, DE (US)
Appl. No. 17/613,475
Filed by SHENZHEN DARMA TECHNOLOGY CO., LTD., Guangdong (CN)
PCT Filed May 20, 2019, PCT No. PCT/CN2019/087640
§ 371(c)(1), (2) Date Nov. 22, 2021,
PCT Pub. No. WO2020/232606, PCT Pub. Date Nov. 26, 2020.
Prior Publication US 2022/0218208 A1, Jul. 14, 2022
Int. Cl. A61B 5/02 (2006.01); A61B 5/00 (2006.01); A61B 5/0205 (2006.01); A61B 5/021 (2006.01); A61B 5/026 (2006.01); A61B 5/11 (2006.01); A61B 5/366 (2021.01)
CPC A61B 5/021 (2013.01) [A61B 5/0205 (2013.01); A61B 5/0261 (2013.01); A61B 5/11 (2013.01); A61B 5/366 (2021.01); A61B 5/7239 (2013.01); A61B 5/7267 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A diastolic function assessment method, comprising to steps of:
acquiring vibration information on a body surface corresponding to thoracic cavity of a subject by means of one or more fiber-optic sensors which are placed under the body of the subject;
preprocessing the vibration information to generate hemodynamic related information;
performing high-frequency component extraction on the hemodynamic related information to generate high-frequency component information; comprising a step of:
performing second-order differential processing on the hemodynamic related information to generate high-frequency component information; or
performing polynomial regression and smoothing on the hemodynamic related information to generate high-frequency component information;
determining a first characteristic value and a second characteristic value based on the hemodynamic related information and the high-frequency component information; where the first characteristic value represents an event of aortic valve opening during the ventricular ejection, and the second characteristic value represents an event that blood flows into the left ventricle and impacts the left ventricular wall in the early ventricular diastole; wherein the event of aortic valve opening during the ventricular ejection comprises vibration on the body surface formed by muscle movement and blood flow movement caused by the aortic valve opening during the ventricular ejection; the event that blood flows into the left ventricle and impacts the left ventricular wall in the early ventricular diastole comprises vibration on the body surface formed by muscle movement and blood flow movement caused by that blood flows into the left ventricle and impacts the left ventricular wall in the early ventricular diastole; the first characteristic value represents a vibration amplitude on the body surface formed by muscle movement and blood flow movement caused by the aortic valve opening during the ventricular ejection, the second characteristic value represents a vibration amplitude on the body surface formed by muscle movement and blood flow movement caused by that blood flows into the left ventricle and impacts the left ventricular wall in the early ventricular diastole; and
generating indicating parameters based on the first characteristic value and the second characteristic value, and evaluating the cardiac diastolic function of the subject based on the indicating parameters.