US 12,226,193 B2
Seizure detection methods, apparatus, and systems using an autoregression algorithm
Ivan Osorio, Leawood, KS (US); Alexey Lyubushin, Moscow (RU); and Didier Sornette, Zurich (CH)
Assigned to Flint Hills Scientific, L.L.C., Lawrence, KS (US)
Filed by Flint Hills Scientific, L.L.C., Lawrence, KS (US)
Filed on May 26, 2023, as Appl. No. 18/202,414.
Application 16/706,688 is a division of application No. 13/559,116, filed on Jul. 26, 2012, granted, now 10,537,251, issued on Jan. 21, 2020.
Application 18/202,414 is a continuation of application No. 16/706,688, filed on Dec. 7, 2019, granted, now 11,672,431.
Claims priority of provisional application 61/547,567, filed on Oct. 14, 2011.
Prior Publication US 2023/0293025 A1, Sep. 21, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 5/0205 (2006.01); A61B 5/16 (2006.01); A61B 5/374 (2021.01); G06F 17/10 (2006.01); A61B 5/024 (2006.01); A61B 5/08 (2006.01); A61B 5/083 (2006.01); A61B 5/11 (2006.01); A61B 5/145 (2006.01); A61B 5/24 (2021.01); A61B 5/369 (2021.01)
CPC A61B 5/02055 (2013.01) [A61B 5/0205 (2013.01); A61B 5/165 (2013.01); A61B 5/374 (2021.01); A61B 5/4094 (2013.01); A61B 5/4836 (2013.01); A61B 5/726 (2013.01); A61B 5/746 (2013.01); G06F 17/10 (2013.01); A61B 5/024 (2013.01); A61B 5/0816 (2013.01); A61B 5/0833 (2013.01); A61B 5/1118 (2013.01); A61B 5/14542 (2013.01); A61B 5/16 (2013.01); A61B 5/24 (2021.01); A61B 5/369 (2021.01)] 12 Claims
OG exemplary drawing
 
1. A non-transitory computer readable program storage unit encoded with instructions that, when executed by one or more medical devices, performs a method, comprising:
receiving via the one or more medical devices a time series of a first body signal of a patient obtained from one or more sensors;
determining a sliding foreground time window and a sliding background time window for the time series of the first body signal;
applying a spectral filter having a defined power spectral density to each of the sliding foreground time window and the sliding background time window;
determining a ratio of a spectral power between the sliding foreground time window and the sliding background time window;
calculating an indicator that a first seizure is occurring in response to a first determination that the ratio reaches an onset threshold;
initiating an electrical therapy based on the seizure onset;
calculating a seizure termination in response to a second determination that the ratio reaches a termination threshold; and
wherein the method further comprises calculating a second seizure occurrence by at least one of:
determining a second seizure occurrence based on an output of a short term average (STA)/long term average (LTA) algorithm on at least one second body signal; and
determining the second seizure occurrence based on a second output of at least one additional algorithm on the first body signal;
wherein the second body signal is selected from an EKG signal, an accelerometer signal, or a signal indicative of a loss of responsiveness.