US 12,226,142 B2
Devices, agents, and associated methods for selective modulation of renal nerves
Robert J. Melder, Santa Rosa, CA (US)
Assigned to Medtronic Ireland Manufacturing Unlimited Company, Dublin (IE)
Filed by Medtronic Ireland Manufacturing Unlimited Company, Dublin (IE)
Filed on Aug. 30, 2021, as Appl. No. 17/461,449.
Application 17/461,449 is a continuation of application No. 16/250,312, filed on Jan. 17, 2019, granted, now 11,116,561.
Claims priority of provisional application 62/606,157, filed on Apr. 20, 2018.
Claims priority of provisional application 62/621,407, filed on Jan. 24, 2018.
Prior Publication US 2021/0386469 A1, Dec. 16, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 18/06 (2006.01); A61K 9/00 (2006.01); A61K 31/165 (2006.01); A61K 47/64 (2017.01); A61M 37/00 (2006.01); A61P 13/12 (2006.01); A61P 25/00 (2006.01); A61B 18/00 (2006.01); A61M 25/10 (2013.01)
CPC A61B 18/06 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0034 (2013.01); A61K 31/165 (2013.01); A61K 47/64 (2017.08); A61M 37/00 (2013.01); A61P 13/12 (2018.01); A61P 25/00 (2018.01); C12Y 302/01017 (2013.01); A61B 2018/0022 (2013.01); A61B 2018/00404 (2013.01); A61B 2018/00434 (2013.01); A61B 2018/00511 (2013.01); A61B 2018/00577 (2013.01); A61M 2025/1015 (2013.01); A61M 2025/1052 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method comprising:
intravascularly positioning a first catheter comprising a first expandable member within a renal artery of a patient;
intravascularly positioning a second catheter comprising a second expandable member within a renal vein of the patient, wherein the renal artery and the renal vein are connected to a kidney of the patient;
expanding the first expandable member to substantially occlude blood flow through the renal artery;
expanding the second expandable member to substantially occlude blood flow through the renal vein;
perfusing a perfusate solution through the kidney of the patient; and
administering a neuromodulatory agent through the kidney via at least one of the first catheter or the second catheter to neuromodulate renal nerves in the patient, wherein the neuromodulatory agent comprises a lipophilic agent coupled to an endogenous carrier molecule, and wherein administering the neuromodulatory agent comprises introducing the neuromodulatory agent to the perfusate solution.