| CPC A61B 17/0057 (2013.01) [A61L 27/045 (2013.01); A61L 27/047 (2013.01); A61L 27/06 (2013.01); A61L 27/18 (2013.01); A61L 27/227 (2013.01); A61L 27/24 (2013.01); A61L 27/3633 (2013.01); A61L 27/3675 (2013.01); A61L 27/54 (2013.01); A61L 31/022 (2013.01); A61L 31/06 (2013.01); A61L 31/14 (2013.01); A61B 2017/00615 (2013.01); A61B 2017/00623 (2013.01); A61B 2017/00659 (2013.01)] | 18 Claims |

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1. A tissue repair and sealing device for use in an open (non-MIS) or minimally invasive surgical (MIS) procedure for rapidly repairing a tissue fenestration and creating a pressure-resistant, watertight seal, said device comprising:
a. an applicator assembly comprising an applicator shaft having a proximal end and a distal end and a clasp retain and release member having a proximal end and a distal end, wherein said clasp retain and release member is movably connected to said applicator shaft and
b. a detachable graft and clasp assembly comprising, in operable combination, a deformable graft subassembly comprising a biodegradable graft fixedly attached directly to a deployable clasp and coupler subassembly comprising a biodegradable clasp and central coupler;
i. wherein said detachable graft and clasp assembly is configured for positioning the biodegradable graft on an inner tissue surface and positioning the biodegradable clasp on an outer tissue surface and
ii. wherein said detachable graft and clasp assembly attaches via the central coupler to the applicator assembly at the proximal end of the applicator shaft.
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