US 12,225,919 B2
Taste-masking formulation for ketone body compounds
Houston Smith, St. Louis, MO (US); Bernadita P. Desierto, Hoffman Estates, IL (US); Beverly Ann Schad, Union, MO (US); Danielle Lasota, Carol Stream, IL (US); and Sean Whittemore, Chesterfield, MO (US)
Assigned to NeuroEnergy Ventures, Inc., New York, NY (US)
Appl. No. 17/433,537
Filed by NeuroEnergy Ventures, Inc., New York, NY (US)
PCT Filed Feb. 21, 2020, PCT No. PCT/US2020/019174
§ 371(c)(1), (2) Date Aug. 24, 2021,
PCT Pub. No. WO2020/185368, PCT Pub. Date Sep. 17, 2020.
Claims priority of provisional application 62/818,208, filed on Mar. 14, 2019.
Prior Publication US 2022/0183327 A1, Jun. 16, 2022
Prior Publication US 2022/0338510 A2, Oct. 27, 2022
Int. Cl. A23L 2/60 (2006.01); A23L 27/00 (2016.01)
CPC A23L 2/60 (2013.01) [A23L 27/84 (2016.08); A23L 27/86 (2016.08)] 11 Claims
 
1. An oral formulation of at least one distasteful ketone body material comprising:
(a) said ketone body material
(b) propylene glycol;
(c) aqueous ethanol;
(d) water in addition to that contributed by said aqueous ethanol, hereinafter “additional water”;
(e) natural or synthetic flavor, comprising at least one flavor oil, at least 90% of the flavor oils being orange flavor oils, grape flavor oils, or a mixture thereof;
(f) high potency sweetener; and
(g) bitter mask agent;
wherein said ketone body material is selected from at least one entity of the group consisting of an alkali metal salt of a ketone body compound, ketone body esters, ketone body amides, and mixtures thereof,
said ketone body compounds are selected from the group consisting of 3-hydroxybutyric acid, and acetoacetic acid;
said ketone body esters are selected from the group consisting of (i) esters between the hydroxyl group of a first 3-hydroxybutyric acid and an acid group of a second ketone body compound, which second ketone body compound is selected from any of said ketone body compounds, (ii) esters between a ketone body compound and a ketone body precursor, (iii) esters between a ketone body compound and glycerin, and (iv) mixtures thereof;
said ketone body amides are selected from the group consisting of amides formed between said ketone body compounds and a physiologically acceptable amine, and wherein said bitter mask agent is is the compound 3-(1-((3,5-Dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxbenzyl)imidazolidine-2,4-dione of Formula

OG Complex Work Unit Chemistry
or a salt or N-oxide thereof.