	US 12,225,906 B1
	Pathogenic affinity pathway of infectious or parasitic organisms for nanogram and picogram dosimetry prophylaxis or cure
Terry Earl Brady, The Valley (AI); Anthony Lee Dellinger, Burlington, NC (US); Lowell Hughes, The Valley (AI); Melinda K. M. Goddard, The Valley (AI); Christopher E. Starr, New York, NY (US); and Abed Alqader Ibrahim, Greensboro, NC (US)
Filed by Terry Earl Brady, The Valley (AI); Anthony Lee Dellinger, Burlington, NC (US); Lowell Hughes, The Valley (AI); Melinda K. M. Goddard, The Valley (AI); Christopher E. Starr, New York, NY (US); and Abed Alqader Ibrahim, Greensboro, NC (US)
Filed on Sep. 26, 2024, as Appl. No. 18/897,019.
Int. Cl. A61K 9/50 (2006.01); A01N 25/10 (2006.01); A01N 59/00 (2006.01); A01N 59/16 (2006.01); A01P 1/00 (2006.01); B82Y 5/00 (2011.01)

CPC A01N 59/16 (2013.01) [A01N 25/10 (2013.01); A01N 59/00 (2013.01); A01P 1/00 (2021.08); A61K 9/5036 (2013.01); B82Y 5/00 (2013.01)]

16 Claims

1. An antimicrobial and nutritive formulation for targeted neutralization of infectious agents, such as bacteria, fungi, viruses, protozoa, and ectoparasites, comprising:

a. a core comprising a biocidal agent encapsulated within a polydopamine coating;

b. sequential layers assembled on said core using a Layer-by-Layer (LbL) assembly technique, wherein each layer comprises a combination of biocompatible materials and chemotactic agents selected to attract specific pathogens;

c. wherein the chemotactic agents mimic natural nutrient sources that stimulate chemotaxis in a targeted organism, wherein the organism is that of a bacteria, fungi, viruses, protozoa, or ectoparasites, thereby enhancing proximity to and ingestion of the biocidal agent;

such that the sequential layers applied to the core comprise a first layer comprising chitosan with a thickness ranging between 10-25 nanometers, a second layer comprising dextran combined with a chemotactic compound comprising glucose with a thickness between 20-25 nanometers and a third layer comprising alginate integrated with lipids with a thickness between 25-50 nanometers.