US 11,901,078 B2
Apparatus, systems, and methods for rapid cancer detection
Satabhisa Mukhopadhyay, Newton, MA (US); and Tathagata Dasgupta, Newton, MA (US)
Assigned to 4D Path Inc., Newton, MA (US)
Filed by 4D Path Inc., Newton, MA (US)
Filed on Oct. 20, 2021, as Appl. No. 17/506,192.
Application 17/506,192 is a continuation of application No. 16/688,910, filed on Nov. 19, 2019, abandoned.
Application 16/688,910 is a continuation of application No. 15/965,664, filed on Apr. 27, 2018, granted, now 10,535,434, issued on Jan. 14, 2020.
Claims priority of provisional application 62/491,774, filed on Apr. 28, 2017.
Prior Publication US 2022/0037025 A1, Feb. 3, 2022
Int. Cl. G06K 9/00 (2022.01); G16H 50/20 (2018.01); G16H 10/40 (2018.01); G06T 7/00 (2017.01); G16H 50/30 (2018.01); G06T 7/10 (2017.01); G16H 30/40 (2018.01); G16H 30/20 (2018.01); G06V 20/69 (2022.01)
CPC G16H 50/20 (2018.01) [G06T 7/0012 (2013.01); G06T 7/10 (2017.01); G06V 20/695 (2022.01); G16H 10/40 (2018.01); G16H 30/20 (2018.01); G16H 30/40 (2018.01); G16H 50/30 (2018.01); G06T 2207/10024 (2013.01); G06T 2207/10048 (2013.01); G06T 2207/30004 (2013.01); G06T 2207/30024 (2013.01)] 21 Claims
OG exemplary drawing
 
1. A method comprising:
receiving, by a processor, data representing at least one cell that has been identified in an area of an image and segmented into a nuclear area and a cellular area;
calculating, by the processor for the at least one cell and based at least in part on the data, a plurality of information surface values each derived as a function of both:
(i) a nuclear contrast feature, wherein the nuclear contrast feature comprises a temperature difference between the nuclear area and the cellular area; and
(ii) a nuclear area feature, wherein the nuclear area feature comprises a ratio of the nuclear area to a nuclear volume projection;
calculating, by the processor, a diagnostic score based at least in part on the plurality of information surface values; and
determining, by the processor based at least in part on the diagnostic score, a normality status of the area of the image.