US 11,899,010 B2
Modular point-of-care devices, systems, and uses thereof
Tammy Burd, Palo Alto, CA (US); Ian Gibbons, Portola Valley, CA (US); Elizabeth A. Holmes, Palo Alto, CA (US); Gary Frenzel, Palo Alto, CA (US); and Anthony Joseph Nugent, Palo Alto, CA (US)
Assigned to Labrador Diagnostics LLC, Wilmington, DE (US)
Filed by Labrador Diagnostics LLC, Wilmington, DE (US)
Filed on May 24, 2022, as Appl. No. 17/664,790.
Application 17/664,790 is a continuation of application No. 15/069,843, filed on Mar. 14, 2016.
Application 15/069,843 is a continuation of application No. 14/670,200, filed on Mar. 26, 2015, granted, now 9,285,366, issued on Mar. 15, 2016.
Application 14/670,200 is a continuation of application No. 13/893,258, filed on May 13, 2013, granted, now 9,121,851, issued on Sep. 1, 2015.
Application 13/893,258 is a continuation of application No. 13/889,674, filed on May 8, 2013, granted, now 8,822,167, issued on Sep. 2, 2014.
Application 13/889,674 is a continuation of application No. 13/326,023, filed on Dec. 14, 2011, granted, now 9,435,793, issued on Sep. 6, 2016.
Application 13/326,023 is a continuation of application No. 12/244,723, filed on Oct. 2, 2008, granted, now 8,088,593, issued on Jan. 3, 2012.
Claims priority of provisional application 60/997,460, filed on Oct. 2, 2007.
Prior Publication US 2022/0283150 A1, Sep. 8, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 33/53 (2006.01); G01N 33/543 (2006.01); B01J 19/00 (2006.01); B01L 3/02 (2006.01); B01L 3/00 (2006.01); G01N 35/02 (2006.01); B01L 9/00 (2006.01); G16H 10/40 (2018.01); G01N 1/38 (2006.01); G01N 33/569 (2006.01); A61B 5/15 (2006.01); A61B 5/151 (2006.01); G01N 35/10 (2006.01); B01L 7/00 (2006.01); G01N 33/68 (2006.01); G01N 33/94 (2006.01); G01N 35/00 (2006.01); G01N 33/574 (2006.01); A61B 10/00 (2006.01); A61B 10/02 (2006.01)
CPC G01N 33/5304 (2013.01) [A61B 5/15 (2013.01); A61B 5/151 (2013.01); A61B 5/150755 (2013.01); B01J 19/0046 (2013.01); B01L 3/0262 (2013.01); B01L 3/5025 (2013.01); B01L 3/527 (2013.01); B01L 7/52 (2013.01); B01L 9/543 (2013.01); G01N 1/38 (2013.01); G01N 33/5302 (2013.01); G01N 33/54326 (2013.01); G01N 33/54366 (2013.01); G01N 33/54386 (2013.01); G01N 33/56966 (2013.01); G01N 33/57484 (2013.01); G01N 33/6803 (2013.01); G01N 33/94 (2013.01); G01N 35/00732 (2013.01); G01N 35/00871 (2013.01); G01N 35/028 (2013.01); G01N 35/10 (2013.01); G01N 35/1065 (2013.01); G01N 35/1074 (2013.01); G16H 10/40 (2018.01); A61B 10/007 (2013.01); A61B 10/0038 (2013.01); A61B 10/0045 (2013.01); A61B 10/0051 (2013.01); A61B 10/0058 (2013.01); A61B 10/02 (2013.01); A61B 2010/0074 (2013.01); A61B 2010/0077 (2013.01); B01J 2219/005 (2013.01); B01J 2219/00283 (2013.01); B01J 2219/00292 (2013.01); B01J 2219/00315 (2013.01); B01J 2219/00369 (2013.01); B01J 2219/00371 (2013.01); B01J 2219/00385 (2013.01); B01J 2219/00466 (2013.01); B01J 2219/00495 (2013.01); B01J 2219/00693 (2013.01); B01J 2219/00702 (2013.01); B01L 3/021 (2013.01); B01L 7/5255 (2013.01); B01L 2200/04 (2013.01); B01L 2200/0689 (2013.01); B01L 2200/141 (2013.01); B01L 2200/148 (2013.01); B01L 2300/0654 (2013.01); B01L 2300/0829 (2013.01); B01L 2300/1805 (2013.01); B01L 2400/043 (2013.01); G01N 2035/0097 (2013.01); G01N 2035/00237 (2013.01); G01N 2035/00851 (2013.01); G01N 2035/00881 (2013.01); G01N 2035/1032 (2013.01); G01N 2035/1034 (2013.01); G01N 2035/1048 (2013.01); G01N 2333/475 (2013.01); G01N 2333/4737 (2013.01); G01N 2333/71 (2013.01); G01N 2333/912 (2013.01); G01N 2333/9129 (2013.01); G01N 2333/91205 (2013.01); G01N 2800/26 (2013.01); G01N 2800/60 (2013.01); Y10T 29/49826 (2015.01); Y10T 436/25375 (2015.01)] 20 Claims
 
1. A system for performing an assay capable of detecting an analyte in a biological sample, the system comprising:
a cartridge comprising:
a plurality of reagent units, wherein one or more of the plurality of reagent units are configured to store cartridge reagents, and
a sample vessel configured to receive the biological sample;
an assay assembly comprising:
an addressable assay unit configured to receive the biological sample and to receive a first cartridge reagent from a first reagent unit of the plurality of reagent units of the cartridge,
a reaction site arranged on an interior surface of the addressable assay unit, wherein the reaction site comprises an immobilized binding reagent configured to bind with the analyte, and
an assembly tip in fluid communication with the addressable assay unit and comprising an opening, wherein the assembly tip is configured to place the addressable assay unit in fluid communication with the first reagent unit or the sample vessel of the cartridge; and
a reader assembly configured to receive the cartridge and the assay assembly, wherein the reader assembly comprises:
an automated fluid transfer device configured to move the assay assembly relative to the cartridge to selectively place the assembly tip of the assay assembly into the sample vessel or into the first reagent unit of the plurality of reagent units and to sequentially transfer the biological sample and the first cartridge reagent into the addressable assay unit via the assembly tip such that a reaction occurs that yields a signal indicative of a presence of the analyte, and
a detection assembly configured to detect the signal indicative of the presence of the analyte.