US 11,898,981 B2
Real-time and label free analyzer for in-vitro and in-vivo detecting the suspicious regions to cancer
Mohammad Abdolahad, Tehran (IR); Zohreh Sadat Miripour, Tehran (IR); Parisa Aghaee, Tehran (IR); Hadi Ghafari, Tehran (IR); Naser Namdar Habashi, Tabriz (IR); and Fereshteh Abbasvandi, Tehran (IR)
Assigned to NANO HESGARSAZAN SALAMAT ARYA INCUBATION CENTER FOR MEDICAL EQUIPMENT AND DEVICES, Tehran (IR)
Filed by Mohammad Abdolahad, Tehran (IR); Zohreh Sadat Miripour, Tehran (IR); Parisa Aghaee, Tehran (IR); Hadi Ghafari, Tehran (IR); Naser Namdar Habashi, Tabriz (IR); and Fereshteh Abbasvandi, Tehran (IR)
Filed on Apr. 13, 2021, as Appl. No. 17/228,859.
Application 17/228,859 is a continuation in part of application No. 16/010,510, filed on Jun. 17, 2018, granted, now 11,181,499.
Claims priority of provisional application 62/563,673, filed on Sep. 27, 2017.
Claims priority of provisional application 62/522,115, filed on Jun. 20, 2017.
Prior Publication US 2021/0231600 A1, Jul. 29, 2021
Int. Cl. G01N 27/327 (2006.01); G01N 27/48 (2006.01); A61B 5/1473 (2006.01); A61B 5/00 (2006.01); G01N 33/483 (2006.01)
CPC G01N 27/3278 (2013.01) [A61B 5/14735 (2013.01); A61B 5/6849 (2013.01); G01N 27/48 (2013.01); G01N 33/4833 (2013.01); A61B 2562/0285 (2013.01); A61B 2562/046 (2013.01); G01N 27/3277 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A probe for non-invasively detecting and tracing cancer, comprising:
a sensing part, comprising:
two reference electrodes comprising a first needle and a second needle, each of the first needle and the second needle comprising a respective hollow needle;
a working electrode comprising a first third needle located inside the first needle, the third needle comprising a first tip coated with a first bilayer coating, the first bilayer coating comprising:
a first layer of silver (Ag) paste coated on the first tip; and
a first layer of carbon nanotubes (CNTs) electrostatically grasped and adhered onto the first layer of Ag paste; and
a counter electrode comprising a fourth needle located inside the second needle, the fourth needle comprising a second tip coated with a second bilayer coating, the second bilayer coating comprising:
a second layer of Ag paste coated on the second tip; and
a second layer of CNTs electrostatically grasped and adhered onto the second layer of Ag paste,
wherein a first respective end of each of the first needle, the second needle, the third needle, and the fourth needle is connected to an electrochemical stimulator-analyzer device via a respective electrical connector, the stimulator-analyzer device configured to measure cyclic voltammetry (CV) based diagrams; and
a holding member, comprising:
an insertion part with two ends, the sensing part attached to a first end of the insertion part, the insertion part configured to facilitate insertion of the sensing part into a target location; and
a button located at a second end of the insertion part, the button coupled with the working electrode and the counter electrode, the button being movable inside the insertion part, the working electrode and the counter electrode configured to be pushed outside the first and second needles through a respective second end of each of the first and second needles when the button is pressed, the working electrode and the counter electrode configured to be pulled inside the two reference electrodes through the respective second end of each of the two reference electrodes when the button is pressed again,
wherein a used sensing part is configured to be replaceable with a fresh sensing part by the used sensing part being configured to be detachable from a first end of the holding member and the fresh sensing part being configured to be attachable to the first end of the holding member.