US 11,898,171 B2
Composition and method for increasing production of bacteriophage using reactive oxygen species
Heejoon Myung, Yongin-si (KR); and Yunyeol Jo, Yongin-si (KR)
Assigned to LYSENTECH, Yongin-si (KR)
Appl. No. 16/642,599
Filed by LyseNTech, Yongin-si (KR)
PCT Filed Aug. 22, 2018, PCT No. PCT/KR2018/009663
§ 371(c)(1), (2) Date Feb. 27, 2020,
PCT Pub. No. WO2019/045356, PCT Pub. Date Mar. 7, 2019.
Claims priority of application No. 10-2017-0108588 (KR), filed on Aug. 28, 2017.
Prior Publication US 2020/0347362 A1, Nov. 5, 2020
Int. Cl. C12N 7/00 (2006.01)
CPC C12N 7/00 (2013.01) [C12N 2795/00051 (2013.01); C12N 2795/10151 (2013.01)] 2 Claims
 
1. A composition for increasing the production of a T4 bacteriophage comprising ROS (Reactive Oxygen Species), the T4 bacteriophage, and a host bacterium, wherein the ROS is comprised at the sublethal concentration for the host bacterium infected by the T4 bacteriophage, wherein the ROS is H202, the concentration is 4.5 mM, and the host bacterium is Escherichia coli.