US 11,898,055 B2
PEM layer-by-layer systems for coating substrates to improve bioactivity and biomolecule delivery
Prashant N. Kumta, Pittsburgh, PA (US); Sangeetha Kunjukunju, Pittsburgh, PA (US); Nicole J. Ostrowski, Pittsburgh, PA (US); Abhijit Roy, Pittsburgh, PA (US); Boeun Lee, Pittsburgh, PA (US); and Madhumati Ramanathan, Hillsboro, OR (US)
Assigned to UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US)
Filed by UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US)
Filed on Oct. 6, 2021, as Appl. No. 17/495,543.
Application 17/495,543 is a division of application No. 14/778,331, granted, now 11,149,166, previously published as PCT/US2014/032790, filed on Apr. 3, 2014.
Claims priority of provisional application 61/807,862, filed on Apr. 3, 2013.
Prior Publication US 2022/0041890 A1, Feb. 10, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C09D 177/04 (2006.01); A61F 2/02 (2006.01); A61L 27/04 (2006.01); A61L 27/34 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01); B05D 7/00 (2006.01); C09D 105/04 (2006.01); C09D 167/04 (2006.01)
CPC C09D 177/04 (2013.01) [A61F 2/02 (2013.01); A61L 27/04 (2013.01); A61L 27/34 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); B05D 7/58 (2013.01); C09D 105/04 (2013.01); C09D 167/04 (2013.01); A61F 2210/0076 (2013.01); A61F 2310/00976 (2013.01); A61L 2300/608 (2013.01); A61L 2420/08 (2013.01)] 15 Claims
 
1. A coated medical implant device, comprising:
a substrate selected from the group comprising magnesium metal, magnesium alloy, iron metal, iron alloy, ferrous metal and ferrous alloy;
a pretreatment agent selected from the group consisting of alkali metal hydroxide, hydrogen fluoride, alkali metal carbonates, and mixtures thereof, applied to a surface of the substrate to form a charged substrate having a positive charge or a negative charge;
a polyelectrolyte multilayer coating deposited on the charged substrate, comprising:
a plurality of interfacing, individual polymer layers, comprising:
at least one polymer layer comprising a first polymer and having a positive charge; and
at least one polymer layer comprising a second polymer and having a negative charge;
wherein an initial polymer layer of the plurality of interfacing, individual polymer layers is deposited on the charged substrate and has a charge opposite the charged substrate, and
wherein an outer polymer layer of the plurality of interfacing, individual polymer layers forms an exterior surface of the charged substrate;
fibronectin immobilized on the exterior surface; and
an active substance, in addition to the fibronectin, deposited on the exterior surface of the charged substrate.