	US 11,897,968 B2
	Anti-MerTK antibodies and methods of use thereof
Seung-Joo Lee, Benicia, CA (US); Spencer Liang, San Mateo, CA (US); Angie Yee, San Francisco, CA (US); Marina Roell, Concord, CA (US); and Arnon Rosenthal, Woodside, CA (US)
Assigned to ALECTOR LLC, South San Francisco, CA (US)
Filed by Alector LLC, South San Francisco, CA (US)
Filed on Dec. 11, 2020, as Appl. No. 17/118,921.
Claims priority of provisional application 63/121,773, filed on Dec. 4, 2020.
Claims priority of provisional application 63/016,821, filed on Apr. 28, 2020.
Claims priority of provisional application 62/947,855, filed on Dec. 13, 2019.
Prior Publication US 2021/0261685 A1, Aug. 26, 2021
Int. Cl. C07K 16/40 (2006.01); A61K 39/395 (2006.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01)

CPC C07K 16/40 (2013.01) [A61P 35/00 (2018.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); A61K 2039/507 (2013.01); C07K 2317/56 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01)]

23 Claims

1. An isolated antibody that binds to human MerTK, wherein the antibody comprises an HVR-H1, HVR-H2, HVR-H3, HVR-L1, HVR-L2, and HVR-L3 comprising the amino acid sequences of:

(i) SEQ ID NOs: 75, 99, 125, 158, 187, and 207, respectively;

(ii) SEQ ID NOs: 76, 100, 126, 159, 187, and 208, respectively;

(iii) SEQ ID NOs: 77, 101, 127, 160, 188, and 209, respectively;

(iv) SEQ ID NOs: 75, 99, 128, 158, 187, and 210, respectively;

(v) SEQ ID NOs: 78, 102, 129, 161, 189, and 211, respectively;

(vi) SEQ ID NOs: 75, 103, 130, 158, 187, and 212, respectively;

(vii) SEQ ID NOs: 77, 101, 127, 162, 188, and 209, respectively;

(viii) SEQ ID NOs: 75, 99, 131, 163, 187, and 213, respectively;

(ix) SEQ ID NOs: 79, 104, 132, 164, 190, and 214, respectively;

(x) SEQ ID NOs: 80, 105, 133, 165, 191, and 215, respectively;

(xi) SEQ ID NOs: 81, 106, 134, 166, 192, and 216, respectively;

(xii) SEQ ID NOs: 82, 107, 135, 167, 193, and 217, respectively;

(xiii) SEQ ID NOs: 77, 108, 136, 167, 194, and 209, respectively;

(xiv) SEQ ID NOs: 75, 109, 137, 168, 187, and 218, respectively;

(xv) SEQ ID NOs: 83, 99, 138, 158, 187, and 210, respectively;

(xvi) SEQ ID NOs: 84, 99, 139, 169, 195, and 219, respectively;

(xvii) SEQ ID NOs: 85, 99, 140, 170, 196, and 220, respectively;

(xviii) SEQ ID NOs: 86, 99, 141, 171, 191, and 221, respectively;

(xix) SEQ ID NOs:87, 110, 142, 172, 197, and 222, respectively;

(xx) SEQ ID NOs: 88, 99, 143, 173, 191, and 223, respectively;

(xxi) SEQ ID NOs: 89, 111, 143, 173, 198, and 221, respectively;

(xxii) SEQ ID NOs: 90, 112, 144, 174, 199, and 224, respectively;

(xxiii) SEQ ID NOs: 91, 113, 145, 175, 200, and 225, respectively;

(xxiv) SEQ ID NOs: 90, 114, 146, 176, 201, and 226, respectively;

(xxv) SEQ ID NOs: 92, 115, 147, 177, 195, and 227, respectively;

(xxvi) SEQ ID NOs: 93, 116, 148, 178, 188, and 209, respectively;

(xxvii) SEQ ID NOs: 94, 117, 149, 179, 195, and 228, respectively;

(xxviii) SEQ ID NOs: 95, 118, 150, 180, 187, and 229, respectively;

(xxix) SEQ ID NOs: 95, 119, 151, 181, 187, and 208, respectively;

(xxx) SEQ ID NOs: 90, 120, 152, 182, 202, and 230, respectively;

(xxxi) SEQ ID NOs: 96, 118, 153, 183, 202, and 230, respectively;

(xxxii) SEQ ID NOs: 96, 121, 154, 181, 187, and 210, respectively;

(xxxiii) SEQ ID NOs: 90, 122, 155, 184, 203, and 231, respectively;

(xxxiv) SEQ ID NOs: 90, 122, 155, 184, 203, and 231, respectively;

(xxxv) SEQ ID NOs:97, 123, 156, 185, 204, and 232, respectively;

(xxxvi) SEQ ID NOs: 98, 124, 157, 186, 205, and 233, respectively;

(xxxvii) SEQ ID NOs: 83, 329, 334, 158, 187, and 210, respectively;

(xxxviii) SEQ ID NOs: 83, 330, 138, 158, 187, and 210, respectively;

(xxxix) SEQ ID NOs: 83, 329, 138, 340, 187, and 210, respectively;

(xl) SEQ ID NOs: 83, 329, 138, 341, 187, and 210, respectively;

(xli) SEQ ID NOs: 83, 329, 335, 341, 187, and 210, respectively;

(xlii) SEQ ID NOs: 83, 331, 138, 341, 187, and 210, respectively;

(xliii) SEQ ID NOs: 83, 329, 138, 342, 187, and 210, respectively;

(xliv) SEQ ID NOs: 83, 329, 336, 341, 187, and 210, respectively;

(xlv) SEQ ID NOs: 83, 329, 337, 343, 187, and 210, respectively;

(xlvi) SEQ ID NOs: 83, 332, 338, 341, 187, and 210, respectively;

(xlvii) SEQ ID NOs: 83, 333, 334, 158, 187, and 210, respectively;

(xlviii) SEQ ID NOs: 83, 332, 336, 341, 187, and 210, respectively;

(xlix) SEQ ID NOs: 83, 329, 339, 344, 187, and 210, respectively;

(l) SEQ ID NOs: 83, 329, 138, 158, 187, and 210, respectively;

(li) SEQ ID NOs: 84, 329, 139, 169, 195, and 219, respectively;

(lii) SEQ ID NOs: 84, 99, 139, 345, 195, and 219, respectively;

(liii) SEQ ID NOs: 346, 348, 355, 341, 187, and 360, respectively;

(liv) SEQ ID NOs: 95, 119, 355, 341, 187, and 361, respectively;

(lv) SEQ ID NOs: 95, 349, 356, 341, 187, and 362, respectively;

(lvi) SEQ ID NOs: 95, 119, 356, 341, 359, and 362, respectively;

(lvii) SEQ ID NOs: 346, 119, 356, 341, 359, and 362, respectively;

(lviii) SEQ ID NOs: 95, 350, 356, 341, 359, and 362, respectively;

(lix) SEQ ID NOs: 95, 351, 356, 341, 359, and 362, respectively;

(lx) SEQ ID NOs: 347, 119, 356, 341, 359, and 362, respectively;

(lxi) SEQ ID NOs: 346, 119, 356, 341, 359, and 362, respectively;

(lxii) SEQ ID NOs: 95, 119, 356, 341, 187, and 362, respectively;

(lxiii) SEQ ID NOs: 95, 352, 356, 341, 187, and 362, respectively;

(lxiv) SEQ ID NOs: 95, 350, 356, 341, 359, and 362, respectively;

(lxv) SEQ ID NOs: 95, 353, 356, 341, 359, and 362, respectively;

(lxvi) SEQ ID NOs: 95, 351, 356, 341, 359, and 362, respectively;

(lxvii) SEQ ID NOs: 95, 350, 356, 341, 359, and 362, respectively;

(lxviii) SEQ ID NOs: 346, 354, 356, 341, 359, and 363, respectively;

(lxix) SEQ ID NOs: 346, 348, 356, 357, 359, and 362, respectively;

(lxx) SEQ ID NOs: 346, 354, 356, 358, 187, and 362, respectively;

(lxxi) SEQ ID NOs: 95, 348, 151, 181, 187, and 208, respectively;

(lxxii) SEQ ID NOs: 90, 364, 373, 376, 388, and 231, respectively;

(lxxiii) SEQ ID NOs: 90, 364, 155, 377, 203, and 231, respectively;

(lxxiv) SEQ ID NOs: 90, 364, 374, 378, 203, and 231, respectively;

(lxxv) SEQ ID NOs: 90, 365, 155, 376, 203, and 392, respectively;

(lxxvi) SEQ ID NOs: 90, 364, 155, 376, 389, and 231, respectively;

(lxxvii) SEQ ID NOs: 90, 364, 155, 379, 203, and 231, respectively;

(lxxviii) SEQ ID NOs: 90, 366, 155, 380, 203, and 231, respectively;

(lxxix) SEQ ID NOs: 90, 364, 373, 381, 203, and 231, respectively;

(lxxx) SEQ ID NOs: 90, 367, 155, 382, 203, and 231, respectively;

(lxxxi) SEQ ID NOs: 90, 368, 155, 383, 203, and 231, respectively;

(lxxxii) SEQ ID NOs: 90, 364, 374, 384, 203, and 231, respectively;

(lxxxiii) SEQ ID NOs: 90, 368, 155, 376, 203, and 293, respectively;

(lxxxiv) SEQ ID NOs: 90, 364, 155, 378, 203, and 231, respectively;

(lxxxv) SEQ ID NOs: 90, 368, 155, 376, 203, and 231, respectively;

(lxxxvi) SEQ ID NOs: 90, 369, 155, 378, 203, and 394, respectively;

(lxxxvii) SEQ ID NOs: 90, 364, 155, 378, 203, and 231, respectively;

(lxxxviii) SEQ ID NOs: 90, 370, 155, 378, 203, and 394, respectively;

(lxxxix) SEQ ID NOs: 90, 371, 155, 378, 203, and 394, respectively;

(xc) SEQ ID NOs: 90, 368, 155, 385, 203, and 394, respectively;

(xci) SEQ ID NOs: 90, 368, 155, 378, 203, and 395, respectively;

(xcii) SEQ ID NOs: 90, 368, 155, 378, 390, and 394, respectively;

(xciii) SEQ ID NOs: 90, 372, 155, 378, 391, and 394, respectively;

(xciv) SEQ ID NOs: 90, 368, 375, 386, 203, and 394, respectively; or

(xcv) SEQ ID NOs: 90, 368, 155, 387, 203, and 394, respectively.