	US 11,897,944 B2
	Immunoglobulin single variable domain (ISVD) capable of binding to serum albumin
Stephanie Staelens, Wevelgem (BE); Soren Steffensen, Etterbeek (BE); Erika Morizzo, Ghent (BE); and An Cerdobbel, Nevele (BE)
Assigned to Ablynx N.V., Zwijnaarde (BE)
Appl. No. 16/477,927
Filed by Ablynx N.V., Ghent-Zwijnaarde (BE)
PCT Filed Jan. 17, 2018, PCT No. PCT/EP2018/051082 § 371(c)(1), (2) Date Jul. 15, 2019, PCT Pub. No. WO2018/134234, PCT Pub. Date Jul. 26, 2018.
Claims priority of provisional application 62/446,992, filed on Jan. 17, 2017.
Prior Publication US 2019/0367598 A1, Dec. 5, 2019
Int. Cl. A61K 39/00 (2006.01); A61K 39/395 (2006.01); C07K 16/00 (2006.01); C07K 16/18 (2006.01)

CPC C07K 16/18 (2013.01) [A61K 2039/505 (2013.01); C07K 2317/22 (2013.01); C07K 2317/24 (2013.01); C07K 2317/50 (2013.01); C07K 2317/56 (2013.01); C07K 2317/569 (2013.01); C07K 2317/62 (2013.01); C07K 2317/622 (2013.01); C07K 2317/624 (2013.01); C07K 2317/626 (2013.01); C07K 2317/92 (2013.01)]

16 Claims

1. An immunoglobulin single variable domain (ISVD) capable of binding to serum albumin that comprises:

a complementarity-determining region 1 (CDR1) having the amino acid sequence GSNISSYVMG (SEQ ID NO: 11) or GSTISSYVMG (SEQ ID NO: 12); and

a complementarity-determining region 2 (CDR2) having the amino acid sequence AISRSGGYTY (SEQ ID NO: 13); and

a complementarity-determining region 3 (CDR3) having the amino acid sequence GRYSAWYSQSYEYDY (SEQ ID NO: 14).