US 11,897,907 B2
Method for preparing glufosinate or analogues thereof
Min Xu, Chengdu (CN); Yongjiang Liu, Chengdu (CN); Lei Zhou, Chengdu (CN); Wei Zeng, Chengdu (CN); and Ke Cheng, Chengdu (CN)
Assigned to LIER CHEMICAL CO., LTD., Mianyang (CN)
Filed by LIER CHEMICAL CO., LTD., Mianyang (CN)
Filed on Apr. 17, 2023, as Appl. No. 18/301,679.
Application 18/301,679 is a continuation of application No. PCT/CN2022/106399, filed on Jul. 19, 2022.
Prior Publication US 2023/0257405 A1, Aug. 17, 2023
Int. Cl. C07F 9/30 (2006.01)
CPC C07F 9/301 (2013.01) 21 Claims
OG exemplary drawing
 
1. A method for preparing a glufosinate of formula (I) or an analogue thereof,

OG Complex Work Unit Chemistry
which method comprises:
a) feeding a compound of formula (II) and a compound of formula (V) into a first reactor set, wherein after reaction, a product stream of the first reactor set is obtained,

OG Complex Work Unit Chemistry
b) feeding the product stream of the first reactor set into a second reactor set, and reacting the product stream at a temperature in the range of from 50° C. to 200° C. to obtain a product stream of the second reactor set; and
c) subjecting the product stream of the second reactor set to an acidic hydrolysis or a basic hydrolysis to obtain the glufosinate of formula (I) or an analogue thereof;
wherein X represents —OR2 or —NR2R′,
R1, R2 and R7 are each independently selected from a substituted or unsubstituted hydrocarbyl group;
R′ is hydrogen or has the same definition as R2;
Hal1 and Hal2 are each independently halogen; and
PG is hydrogen or an amino protecting group; and
wherein the feeding in the step a) and/or step b) is/are a continuous feeding.