US 11,897,889 B2
Process and intermediates for preparing a JAK1 inhibitor
Jiacheng Zhou, Newark, DE (US); Shili Chen, Newark, DE (US); Pingli Liu, Wilmington, DE (US); David J. Meloni, Bear, DE (US); Yongchun Pan, Wilmington, DE (US); Naijing Su, Hockessin, DE (US); and Michael Xia, Wilmington, DE (US)
Assigned to Incyte Corporation, Wilmington, DE (US)
Filed by Incyte Corporation, Wilmington, DE (US)
Filed on Aug. 17, 2021, as Appl. No. 17/404,461.
Claims priority of provisional application 63/067,062, filed on Aug. 18, 2020.
Prior Publication US 2022/0056034 A1, Feb. 24, 2022
Int. Cl. C07D 487/04 (2006.01); C07D 205/04 (2006.01); C07D 401/14 (2006.01)
CPC C07D 487/04 (2013.01) [C07D 205/04 (2013.01); C07D 401/14 (2013.01)] 69 Claims
 
1. A process of preparing itacitinib, or a salt thereof, comprising:
reacting a compound of formula 3:

OG Complex Work Unit Chemistry
 or a salt thereof, with a reagent selected from (i) a salt of formula 2a, or a salt thereof, and (ii) a compound of formula 2b:

OG Complex Work Unit Chemistry
 wherein X− is a counter anion.