US 11,897,844 B2
Method for producing amino acid derivatives
Masato Murai, Tokyo (JP); Jun Takehara, Tokyo (JP); and Daiki Okado, Tokyo (JP)
Assigned to API CORPORATION, Fukuoka (JP)
Appl. No. 17/277,456
Filed by API CORPORATION, Fukuoka (JP)
PCT Filed Sep. 24, 2019, PCT No. PCT/JP2019/037399
§ 371(c)(1), (2) Date Mar. 18, 2021,
PCT Pub. No. WO2020/059891, PCT Pub. Date Mar. 26, 2020.
Claims priority of application No. 2018-177774 (JP), filed on Sep. 21, 2018.
Prior Publication US 2021/0403427 A1, Dec. 30, 2021
Int. Cl. C07D 211/60 (2006.01)
CPC C07D 211/60 (2013.01) 3 Claims
 
1. A method for producing a compound represented by the formula (2):

OG Complex Work Unit Chemistry
wherein PG1 is an amino-protecting group, PG2 is an amino-protecting group, PG3 is a hydroxyl-protecting group, LG is a leaving group, and R is a hydrocarbon group having 1-8 carbon atoms and optionally having substituent(s), wherein the leaving group is a sulfonyloxy group,
comprising
reacting
a compound represented by the formula (1):

OG Complex Work Unit Chemistry
wherein each symbol is as defined above, with
a hydroxylamine derivative represented by the formula PG2NHOPG3 wherein each symbol is as defined above in the presence of a base in a solvent.