US 11,897,832 B2
Method for preparing partially fluorinated alcohol
Andrew Sharratt, Runcorn (GB); David Grundy, Runcorn (GB); and Ira Saxena, Runcorn (GB)
Assigned to MEXICHEM FLUOR S.A. DE C.V., San Luis Potosi (MX)
Appl. No. 17/439,523
Filed by Mexichem Fluor S.A. de C.V., San Luis Potosi (MX)
PCT Filed Mar. 18, 2020, PCT No. PCT/GB2020/050701
§ 371(c)(1), (2) Date Sep. 15, 2021,
PCT Pub. No. WO2020/188274, PCT Pub. Date Sep. 24, 2020.
Claims priority of application No. 1903909 (GB), filed on Mar. 21, 2019.
Prior Publication US 2022/0153668 A1, May 19, 2022
Int. Cl. C07C 29/64 (2006.01); C07B 39/00 (2006.01); C07C 29/62 (2006.01)
CPC C07C 29/64 (2013.01) [C07B 39/00 (2013.01); C07C 29/62 (2013.01)] 25 Claims
OG exemplary drawing
 
1. A method for preparing a partially fluorinated alcohol, comprising:
reacting an epoxide:

OG Complex Work Unit Chemistry
with a fluorinating agent;
wherein R1, R2, R3 and R4 are independently selected from the group consisting of H, F, Cl, Br, I, CF3, alkyl, fluoroalkyl, and haloalkyl; where at least one of R1, R2, R3 and R4 is —CF3, and at least one of R1, R2, R3 and R4 is —H.