US 11,896,736 B2
Biomaterial implants and methods of making the same
Joshua Cige, Conshohocken, PA (US); Archana Bhat, Phoenixville, PA (US); and Joanna Marquez, San Antonio, TX (US)
Assigned to Globus Medical, Inc, Audubon, PA (US)
Filed by GLOBUS MEDICAL, INC., Audubon, PA (US)
Filed on Jul. 13, 2020, as Appl. No. 16/926,905.
Prior Publication US 2022/0008615 A1, Jan. 13, 2022
Int. Cl. A61L 27/36 (2006.01); A61L 27/56 (2006.01)
CPC A61L 27/3608 (2013.01) [A61L 27/365 (2013.01); A61L 27/3616 (2013.01); A61L 27/3683 (2013.01); A61L 27/56 (2013.01); A61L 2430/02 (2013.01); A61L 2430/40 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method of making an implantable biomaterial for aiding bone regeneration, the method comprising:
obtaining whole bone;
sectioning and debriding the whole bone into cortical rings;
machining the cortical rings into cortical fibers having lengths of 10-50 mm, widths of 0.5-2 mm, and thicknesses of 0.1-1 mm;
demineralizing the cortical fibers to form demineralized cortical fibers;
suspending and entangling the demineralized cortical fibers in an aqueous solution;
compressing the demineralized cortical fibers in solution in a mold to form a molded biomaterial composition of a given shape;
freezing the molded biomaterial composition; and
freeze-drying the molded biomaterial composition to form the implantable biomaterial;
wherein the cortical rings are cleaned with a 0.05-0.15% v/v sodium deoxycholate solution, a 2-6% hydrogen peroxide solution, and an isopropyl alcohol solution.