	US 11,896,715 B2
	In vivo bulking agent, injection comprising same, and preparation method therefor
Kwang Dae Hong, Gyeonggi-do (KR); Jihun Seo, Seoul (KR); and Joon Bum Lee, Chungcheongbuk-do (KR)
Assigned to KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, Seoul (KR)
Appl. No. 17/621,587
Filed by KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, Seoul (KR)
PCT Filed Jun. 11, 2020, PCT No. PCT/KR2020/007557 § 371(c)(1), (2) Date Dec. 21, 2021, PCT Pub. No. WO2020/256340, PCT Pub. Date Dec. 24, 2020.
Claims priority of application No. 10-2019-0073898 (KR), filed on Jun. 21, 2019; and application No. 10-2019-0075727 (KR), filed on Jun. 25, 2019.
Prior Publication US 2022/0354790 A1, Nov. 10, 2022
Int. Cl. A61K 47/36 (2006.01); A61K 47/42 (2017.01); A61K 9/16 (2006.01); A61K 9/00 (2006.01); A61K 9/50 (2006.01)

CPC A61K 9/1641 (2013.01) [A61K 9/0019 (2013.01); A61K 9/5026 (2013.01); A61K 47/36 (2013.01); A61K 47/42 (2013.01)]

14 Claims

1. An in-vivo bulking agent formulated as an injectable composition, comprising:

a first composition including polydimethylsiloxane (PDMS) particles and a zwitterionic polymer surrounding a surface of the polydimethylsiloxane particles; and

a second composition having a viscosity of 100 to 1500 cps at room temperature, wherein the zwitterionic polymer of the first composition has a surfactant property, and wherein the zwitterionic polymer is included in an amount of 0.1 to 5 parts by weight of based on 100 parts by weight of the polydimethylsiloxane particles and the zwitterionic polymer is a random copolymer including a first monomer having a zwitterion ion and a second monomer containing an acrylic acid ester, wherein the first monomer is one or more selected from the group consisting of methacryloyloxyethyl phosphorylcholine (MPC), carboxybetaine methacrylate (CBMA), and sulfobetaine methacrylate (SBMA).