US 11,896,681 B2
Particles comprising bilirubin derivative and metal
Sang Yong Jon, Daejeon (KR); Dong Yun Lee, Daejeon (KR); Yong Hyun Lee, Daejeon (KR); Do Hyun Yoo, Daejeon (KR); and Won Sik Jung, Daejeon (KR)
Assigned to BILIX CO., LTD., Seoul (KR)
Appl. No. 16/343,043
Filed by BILIX CO., LTD., Seoul (KR)
PCT Filed May 14, 2018, PCT No. PCT/KR2018/005515
§ 371(c)(1), (2) Date Apr. 18, 2019,
PCT Pub. No. WO2018/208137, PCT Pub. Date Nov. 15, 2018.
Claims priority of application No. 10-2017-0059597 (KR), filed on May 12, 2017.
Prior Publication US 2020/0230261 A1, Jul. 23, 2020
Int. Cl. A61K 49/00 (2006.01); A61K 49/10 (2006.01); A61K 33/243 (2019.01); A61K 33/242 (2019.01); A61K 33/26 (2006.01); A61K 47/22 (2006.01); G01N 33/72 (2006.01)
CPC A61K 49/106 (2013.01) [A61K 33/242 (2019.01); A61K 33/243 (2019.01); A61K 33/26 (2013.01); A61K 47/22 (2013.01); G01N 33/728 (2013.01)] 11 Claims
 
1. A bilirubin chelate complex comprising:
a plurality of bilirubins each conjugated with a hydrophilic molecule; and
a metal nanoparticle attached by coordinate bonds to at least one of a carboxyl group, a lactam group, or a pyrrole ring of the bilirubin,
wherein the bilirubin chelate complex has a shell-core shape comprising a shell formed by the plurality of bilirubins, and the hydrophilic molecule conjugated with each of the plurality of bilirubins extends from the shell,
wherein the metal nanoparticle comprises a superparamagnetic iron oxide nanoparticle (SPION) or a gold nanoparticle;
the metal nanoparticle is within a core of the shell-core shape; and
the metal nanoparticle within the core is coated with a single layer of the shell formed by the plurality of bilirubins.