US 11,896,680 B2
Detection method
Akira Mizoguchi, Tsu (JP); Koji Tanaka, Tsu (JP); Kazushi Kimura, Tsu (JP); Tetsuya Nosaka, Tsu (JP); Kyosuke Tanaka, Tsu (JP); Shujie Wang, Tsu (JP); Aika Kaito, Tsu (JP); Kousyoku Sai, Tsu (JP); Yuji Toiyama, Tsu (JP); Hidemasa Goto, Tsu (JP); Masahiko Sugimoto, Tsu (JP); and Yuuhei Nishimura, Tsu (JP)
Assigned to MIE University, Mie (JP)
Appl. No. 16/762,906
Filed by Mie University, Tsu (JP)
PCT Filed Nov. 27, 2018, PCT No. PCT/JP2018/043636
§ 371(c)(1), (2) Date May 8, 2020,
PCT Pub. No. WO2019/107370, PCT Pub. Date Jun. 6, 2019.
Claims priority of application No. 2017-228477 (JP), filed on Nov. 28, 2017.
Prior Publication US 2021/0169315 A1, Jun. 10, 2021
Int. Cl. A61K 49/00 (2006.01); A61B 1/00 (2006.01); A61B 1/04 (2006.01); A61B 1/06 (2006.01); A61B 1/31 (2006.01); G01N 21/64 (2006.01); A61B 5/00 (2006.01)
CPC A61K 49/006 (2013.01) [A61B 1/00055 (2013.01); A61B 1/000094 (2022.02); A61B 1/043 (2013.01); A61B 1/063 (2013.01); A61B 1/31 (2013.01); A61B 5/0071 (2013.01); G01N 21/6486 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method for detecting cancer progression comprising staining an organ tissue suspected of having cancer with curcumin and then laser irradiating the organ tissue from serosal side or lumen using a multiphoton laser microscopic endoscope, confocal laser microscopic endoscope or laser fluorescent microscopic endoscope, and visualizing Meissner's plexus or Auerbach's plexus present in the organ tissue, wherein the organ tissue is digestive tract tissue, and a primary lesion is in mucosal epithelium.