US 11,896,668 B2
Lyophilized preparation of cytotoxic dipeptides
Jack Spira, Tyreso (SE); and Fredrik Lehmann, Knivsta (SE)
Assigned to Oncopeptides AB, Stockholm (SE)
Filed by ONCOPEPTIDES AB, Stockholm (SE)
Filed on Apr. 27, 2022, as Appl. No. 17/730,398.
Application 17/730,398 is a division of application No. 16/935,372, filed on Jul. 22, 2020, granted, now 11,344,622.
Application 16/935,372 is a division of application No. 16/721,639, filed on Dec. 19, 2019, granted, now 10,869,928, issued on Dec. 22, 2020.
Application 16/721,639 is a division of application No. 16/457,102, filed on Jun. 28, 2019, abandoned.
Application 16/457,102 is a division of application No. 14/113,768, abandoned, previously published as PCT/EP2012/057577, filed on Apr. 25, 2012.
Claims priority of provisional application 61/535,126, filed on Sep. 15, 2011.
Claims priority of application No. 1150371-1 (SE), filed on Apr. 28, 2011.
Prior Publication US 2022/0323585 A1, Oct. 13, 2022
Int. Cl. A61K 47/40 (2006.01); A61K 38/00 (2006.01); A61K 47/10 (2017.01); A61K 9/19 (2006.01); A61K 31/195 (2006.01); A61K 38/05 (2006.01); A61K 47/12 (2006.01); F26B 5/06 (2006.01); A61K 38/10 (2006.01); A61K 47/26 (2006.01); A61K 31/222 (2006.01); A61K 47/02 (2006.01)
CPC A61K 47/10 (2013.01) [A61K 9/19 (2013.01); A61K 31/195 (2013.01); A61K 31/222 (2013.01); A61K 38/00 (2013.01); A61K 38/05 (2013.01); A61K 38/105 (2013.01); A61K 47/02 (2013.01); A61K 47/12 (2013.01); A61K 47/26 (2013.01); A61K 47/40 (2013.01); F26B 5/06 (2013.01)] 21 Claims
 
1. A lyophilized pharmaceutical preparation which is directly soluble in a physiologically acceptable aqueous solution, comprising (i) melphalan flufenamide or a pharmaceutically acceptable salt thereof and (ii) hydroxypropyl-β-cyclodextrin and/or sulfobutylether-β-cyclodextrin.