US 11,896,666 B2
Adjuvant compositions
Paul Joseph Dominowski, Kalamazoo, MI (US); Ramasamy Mannar Mannan, Woburn, MA (US); Richard Lee Krebs, Ashland, NE (US); James Richard Thompson, Portage, MI (US); Tedd Alan Childers, Portage, MI (US); Mary Kathryn Olsen, Kalamazoo, MI (US); Robert John Yancey, Jr., Portage, MI (US); Risini Dhammika Weeratna, Ottawa (CA); Shucheng Zhang, Shanghai (CN); and Cedo Martin Bagi, Branford, CT (US)
Assigned to Zoetis Services LLC, Parsippany, NJ (US)
Filed by Zoetis Services LLC, Parsippany, NJ (US)
Filed on Mar. 8, 2021, as Appl. No. 17/195,003.
Application 14/013,299 is a division of application No. 12/490,767, filed on Jun. 24, 2009, granted, now 8,580,280, issued on Nov. 12, 2013.
Application 17/195,003 is a continuation of application No. 15/933,805, filed on Mar. 23, 2018, granted, now 10,940,202, issued on Mar. 9, 2021.
Application 15/933,805 is a continuation of application No. 15/494,920, filed on Apr. 26, 2017, granted, now 10,238,736, issued on Mar. 26, 2019.
Application 15/494,920 is a continuation of application No. 14/013,299, filed on Aug. 29, 2013, granted, now 9,662,385, issued on May 30, 2017.
Claims priority of provisional application 61/214,557, filed on Apr. 24, 2009.
Claims priority of provisional application 61/076,232, filed on Jun. 27, 2008.
Prior Publication US 2021/0338810 A1, Nov. 4, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/39 (2006.01); A61K 39/012 (2006.01); A61K 39/108 (2006.01); A61K 39/12 (2006.01); A61K 39/145 (2006.01); A61K 39/00 (2006.01); A61K 39/02 (2006.01); A61K 39/15 (2006.01); A61K 39/21 (2006.01); A61K 39/215 (2006.01); A61P 37/02 (2006.01); A61K 39/002 (2006.01)
CPC A61K 39/39 (2013.01) [A61K 39/002 (2013.01); A61K 39/0011 (2013.01); A61K 39/012 (2013.01); A61K 39/0208 (2013.01); A61K 39/0241 (2013.01); A61K 39/0258 (2013.01); A61K 39/12 (2013.01); A61K 39/145 (2013.01); A61K 39/15 (2013.01); A61K 39/21 (2013.01); A61K 39/215 (2013.01); A61P 37/02 (2018.01); A61K 2039/521 (2013.01); A61K 2039/5252 (2013.01); A61K 2039/5254 (2013.01); A61K 2039/54 (2013.01); A61K 2039/55 (2013.01); A61K 2039/552 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/55511 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55561 (2013.01); A61K 2039/55566 (2013.01); A61K 2039/55572 (2013.01); A61K 2039/55577 (2013.01); C12N 2720/12334 (2013.01); C12N 2720/12351 (2013.01); C12N 2740/13034 (2013.01); C12N 2740/13051 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16151 (2013.01); C12N 2770/20034 (2013.01); C12N 2770/20051 (2013.01); C12N 2770/24334 (2013.01); C12N 2770/24351 (2013.01); Y02A 50/30 (2018.01)] 7 Claims
 
1. An adjuvant composition comprising a saponin, a sterol, a quaternary ammonium compound, a polymer, and N-(2-deoxy-2-L-leucylamino-β-D-glucopyranosyl)-N-octadecyldodecanamide acetate, wherein the saponin is Quil A or a purified faction thereof, the sterol is cholesterol, the quaternary ammonium compound is dimethyl dioctadecyl ammonium bromide (DDA), the polymer is polyacrylic acid.