	US 11,896,661 B2
	Influenza virus vaccine and method of making
Xiu-Feng Wan, Starkville, MS (US); and Feng Wang, Starkville, MS (US)
Assigned to Mississippi State University, Starkville, MS (US)
Appl. No. 16/608,662
Filed by Mississippi State University, Starkville, MS (US)
PCT Filed Apr. 27, 2018, PCT No. PCT/US2018/029945 § 371(c)(1), (2) Date Oct. 25, 2019, PCT Pub. No. WO2018/201044, PCT Pub. Date Nov. 1, 2018.
Claims priority of provisional application 62/490,654, filed on Apr. 27, 2017.
Prior Publication US 2020/0188507 A1, Jun. 18, 2020
Int. Cl. A61K 39/145 (2006.01); C07K 14/005 (2006.01); C12N 9/24 (2006.01); C12Q 1/70 (2006.01)

CPC A61K 39/145 (2013.01) [C07K 14/005 (2013.01); C12N 9/2402 (2013.01); C12Q 1/70 (2013.01); C12N 2760/16122 (2013.01); C12N 2760/16134 (2013.01)]

4 Claims

1. The method of using Y161F mutation in hemagglutinin to generate seed virus of high yield for influenza vaccine development and production, comprising using site-directed mutagenesis to create mutation Y161F in hemagglutinin of influenza virus.