	US 11,896,632 B2
	Methods for inhibiting growth of oral pathogenic bacteria and alleviating oral pathogenic bacteria-associated disorder
Hsieh-Hsun Ho, Tainan (TW); Yi-Wei Kuo, Tainan (TW); Ching-Wei Chen, Tainan (TW); Wen-Yang Lin, Tainan (TW); Jui-Fen Chen, Tainan (TW); and Shu-Hui Chen, Tainan (TW)
Assigned to GLAC BIOTECH CO., LTD., Tainan (TW)
Filed by GLAC BIOTECH CO., LTD., Tainan (TW)
Filed on Jan. 11, 2022, as Appl. No. 17/573,049.
Claims priority of application No. 202110843603.8 (CN), filed on Jul. 26, 2021.
Prior Publication US 2023/0036629 A1, Feb. 2, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/747 (2015.01); A61P 31/04 (2006.01); A61K 8/99 (2017.01); C12N 1/20 (2006.01); C12R 1/225 (2006.01); A61Q 11/00 (2006.01)

CPC A61K 35/747 (2013.01) [A61K 8/99 (2013.01); A61P 31/04 (2018.01); C12N 1/205 (2021.05); A61Q 11/00 (2013.01); C12R 2001/225 (2021.05)]

8 Claims

1. A method for inhibiting growth of oral pathogenic bacteria, comprising applying a composition including liquid cultures of Lactobacillus rhamnosus MP108 and Lactobacillus paracasei MP137, which are deposited at the China General Microbiological Culture Collection Center (CGMCC) under accession numbers CGMCC 21225 and CGMCC 21224, respectively,

wherein the liquid cultures are substantially free of bacterial cells, and a volume ratio of the liquid cultures of Lactobacillus rhamnosus MP108 and Lactobacillus paracasei MP137 in the composition ranges from 1:0.43 to 1:2.33.