US 11,896,622 B2
Methods of producing pancreatic hormones
Laura Martinson, San Diego, CA (US); Evert Kroon, San Diego, CA (US); Kevin D'Amour, San Diego, CA (US); and Emmanuel Edward Baetge, Encinitas, CA (US)
Assigned to ViaCyte, Inc., San Diego, CA (US)
Filed by ViaCyte, Inc., San Diego, CA (US)
Filed on Nov. 8, 2019, as Appl. No. 16/679,100.
Application 16/679,100 is a continuation of application No. 15/961,720, filed on Apr. 24, 2018, granted, now 10,517,901.
Application 15/961,720 is a continuation of application No. 14/670,249, filed on Mar. 26, 2015, granted, now 9,980,986, issued on May 29, 2018.
Application 14/670,249 is a continuation of application No. 13/205,511, filed on Aug. 8, 2011, granted, now 9,585,917, issued on Mar. 7, 2017.
Application 13/205,511 is a continuation of application No. 12/758,734, filed on Apr. 12, 2010, granted, now 7,993,920, issued on Aug. 9, 2011.
Application 12/758,734 is a continuation of application No. 11/773,944, filed on Jul. 5, 2007, granted, now 7,695,965, issued on Apr. 13, 2010.
Application 11/773,944 is a continuation in part of application No. 11/681,687, filed on Mar. 2, 2007, granted, now 8,129,182, issued on Mar. 6, 2012.
Claims priority of provisional application 60/852,878, filed on Oct. 18, 2006.
Claims priority of provisional application 60/833,633, filed on Jul. 26, 2006.
Claims priority of provisional application 60/778,649, filed on Mar. 2, 2006.
Prior Publication US 2020/0316135 A1, Oct. 8, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/39 (2015.01); C12N 5/071 (2010.01); A61K 38/26 (2006.01); A61K 38/28 (2006.01); A61K 35/12 (2015.01)
CPC A61K 35/39 (2013.01) [A61K 38/26 (2013.01); A61K 38/28 (2013.01); C12N 5/0676 (2013.01); C12N 5/0678 (2013.01); A61K 35/12 (2013.01); C12N 2500/38 (2013.01); C12N 2501/10 (2013.01); C12N 2501/105 (2013.01); C12N 2501/113 (2013.01); C12N 2501/115 (2013.01); C12N 2501/119 (2013.01); C12N 2501/12 (2013.01); C12N 2501/16 (2013.01); C12N 2501/33 (2013.01); C12N 2501/385 (2013.01); C12N 2501/41 (2013.01); C12N 2501/415 (2013.01); C12N 2501/42 (2013.01); C12N 2501/58 (2013.01); C12N 2501/999 (2013.01); C12N 2506/02 (2013.01)] 14 Claims
 
1. A method for producing insulin in a human subject in need thereof, comprising: maturing in vivo a cell population comprising human PDX-1 positive pancreatic cells that has been transplanted into the human subject,
thereby obtaining insulin secreting cells that secrete insulin in response to glucose stimulation, and producing insulin in the human subject.