US 11,896,392 B2
Systems and methods for non-invasive fat composition measurement in an organ
Pablo Jose Prado, San Diego, CA (US); and Alejandro Bussandri, San Diego, CA (US)
Assigned to Livivos Inc., San Diego, CA (US)
Filed by Livivos Inc., San Diego, CA (US)
Filed on Mar. 10, 2022, as Appl. No. 17/692,002.
Claims priority of provisional application 63/159,346, filed on Mar. 10, 2021.
Prior Publication US 2022/0287635 A1, Sep. 15, 2022
Int. Cl. A61B 5/00 (2006.01); A61B 5/055 (2006.01); G01R 33/48 (2006.01)
CPC A61B 5/4872 (2013.01) [A61B 5/055 (2013.01); G01R 33/4828 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A non-invasive health measurement system comprising:
an open magnet Nuclear Magnetic Resonance (“NMR”) apparatus to obtain NMR response signals generated by atomic nuclei of substances comprising an organ, the NMR response signals comprising a fat contribution signal and a water contribution signal;
a processor; and
a memory communicably coupled to the processor and storing instructions that, when executed by the processor, cause the processor to:
transmit radio frequency (“RF”) pulses in a presence of a field gradient into the organ with the open magnet NMR apparatus;
obtain the NMR response signals; and
separate contributions of water and fat to the NMR response signals based on a difference in diffusion coefficients of water and fat to determine a water composition and a fat composition of the organ by measuring the NMR response signals' amplitude dependence with diffusion time and determining amplitude and diffusion coefficients of fat and water contributions using the measured amplitude dependence with diffusion time.