	US 11,895,994 B2
	Humanized knock-in mouse expressing human Protein C
Jun Xu, Shanghai (CN); Lu Cheng, Shanghai (CN); Yeheng Liu, Shanghai (CN); Jiawei Yi, Shanghai (CN); and Xuefeng Zhou, Shanghai (CN)
Assigned to Shanghai RAAS Blood Products Co., Ltd., Shanghai (CN)
Filed by Shanghai RAAS Blood Products Co., Ltd., Shanghai (CN)
Filed on Sep. 3, 2020, as Appl. No. 17/011,292.
Claims priority of application No. 201911027061.6 (CN), filed on Oct. 27, 2019; and application No. 1915689 (GB), filed on Oct. 29, 2019.
Prior Publication US 2021/0120789 A1, Apr. 29, 2021
Int. Cl. A01K 67/027 (2006.01); C12N 5/0735 (2010.01); C12N 15/85 (2006.01)

CPC A01K 67/0278 (2013.01) [A01K 67/0276 (2013.01); C12N 5/0606 (2013.01); C12N 15/8509 (2013.01); A01K 2207/15 (2013.01); A01K 2217/052 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); C12N 2015/8527 (2013.01)]

6 Claims

1. A genetically modified mouse, in which both copies of the endogenous nucleotide sequence encoding Protein C in the genome of said mouse have been replaced by a nucleotide sequence encoding human Protein C.