US 12,224,045 B2
Systems and methods for prediction of protein formulation properties
Cindy Ren, Calabasas, CA (US); Mohan B. Boggara, Thousand Oaks, CA (US); Nitin Rathore, Thousand Oaks, CA (US); and Behnam Partopour, Cambridge, MA (US)
Assigned to AMGEN INC., Thousand Oaks, CA (US)
Appl. No. 17/638,395
Filed by AMGEN INC., Thousand Oaks, CA (US)
PCT Filed Aug. 25, 2020, PCT No. PCT/US2020/047755
§ 371(c)(1), (2) Date Feb. 25, 2022,
PCT Pub. No. WO2021/041384, PCT Pub. Date Mar. 4, 2021.
Claims priority of provisional application 62/891,541, filed on Aug. 26, 2019.
Prior Publication US 2022/0293223 A1, Sep. 15, 2022
Int. Cl. G16C 20/30 (2019.01); G16C 20/50 (2019.01); G16C 20/70 (2019.01)
CPC G16C 20/30 (2019.02) [G16C 20/50 (2019.02); G16C 20/70 (2019.02)] 21 Claims
OG exemplary drawing
 
1. A method of predicting a property of potential protein formulations, the method comprising:
classifying, by one or more processors of a computing system, a set of formulation descriptors as belonging to a specific group of a plurality of predetermined groups that each correspond to a different value range for a protein formulation property, wherein classifying the set of formulation descriptors includes applying at least a first portion of the set of formulation descriptors as inputs to a first machine learning model;
selecting, by the one or more processors and based on the specific group, a second machine learning model from among a plurality of machine learning models that each correspond to a different one of the plurality of predetermined groups;
predicting, by the one or more processors, a value of the protein formulation property by applying at least a second portion of the set of formulation descriptors as inputs to the second machine learning model; and
causing, by the one or more processors, the value of the protein formulation property to be one or both of (i) displayed to a user, and (ii) stored in a memory.