| CPC G06F 30/392 (2020.01) [G06F 2119/06 (2020.01); H01L 23/481 (2013.01); H01L 27/0886 (2013.01); H01L 29/0653 (2013.01)] | 20 Claims |

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1. A method, comprising:
generating an integrated circuit (IC) layout design, comprising:
generating a pattern of a through-substrate via (TSV) region in a keep-out-zone (KOZ);
generating a pattern of first channel regions of first transistors in a layout region surrounding the KOZ;
generating a pattern of second channel regions of second transistors in the KOZ, wherein the first channel regions of the first transistors and the second channel regions of the second transistors are spaced apart from the TSV region, and the second channel regions of the second transistors are substantially identical in channel width; and
manufacturing an IC based on the IC layout design.
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