US 12,222,339 B2
Establishing fluidic connections between chromatography components
Wade P. Leveille, Douglas, MA (US); Joseph D. Michienzi, Plainville, MA (US); Joseph D. Antocci, Leominster, MA (US); and Jeffrey Musacchio, Sharon, MA (US)
Assigned to Waters Technologies Corporation, Milford, MA (US)
Filed by Waters Technologies Corporation, Milford, MA (US)
Filed on Oct. 20, 2023, as Appl. No. 18/491,132.
Application 18/491,132 is a continuation of application No. 17/239,813, filed on Apr. 26, 2021, granted, now 11,796,516.
Claims priority of provisional application 63/017,249, filed on Apr. 29, 2020.
Prior Publication US 2024/0044852 A1, Feb. 8, 2024
Int. Cl. G01N 30/60 (2006.01)
CPC G01N 30/6026 (2013.01) [G01N 30/6047 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A column enclosure for a chromatography column comprising:
a column housing extending along a length;
a rail extending along the length within the column housing;
a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage including an actuator and a stop mechanism;
a first fluidic assembly configured to be moved by the actuator into engagement with a chromatography column received within the column housing; and
a second fluidic assembly located proximate an end of the rail;
wherein the stop mechanism is configured to selectively prevent and allow movement of the carriage relative to the rail, wherein the stop mechanism is configured to be independently operable from the actuator, and wherein engaging the actuator is configured to simultaneously establish two fluid tight seals including:
a first fluid tight seal between the first fluidic assembly and the chromatography column, wherein the engaging the actuator is configured to operably move the first fluidic assembly into engagement with the chromatography column to create the first fluid tight seal; and
a second fluid tight seal between the second fluidic assembly and the chromatography column, wherein the engaging the actuator is configured to simultaneously push the chromatography column into the second fluid tight seal with the second fluidic assembly.