US 12,222,279 B2
Flow cell device and bioreactor product monitoring system and method
Bryan A. Hassell, Cambridge, MA (US); and Aaron Delahanty, Freeville, NY (US)
Assigned to Nirrin Technologies, Inc., Billerica, MA (US)
Filed by Nirrin Technologies, Inc., Billerica, MA (US)
Filed on Jan. 24, 2020, as Appl. No. 16/751,895.
Claims priority of provisional application 62/796,400, filed on Jan. 24, 2019.
Prior Publication US 2020/0240902 A1, Jul. 30, 2020
Int. Cl. G01N 21/03 (2006.01); B01L 3/00 (2006.01); C12M 1/00 (2006.01); G01N 21/05 (2006.01)
CPC G01N 21/0332 (2013.01) [B01L 3/502 (2013.01); C12M 47/20 (2013.01); G01N 21/05 (2013.01); B01L 2200/0689 (2013.01); B01L 2300/0663 (2013.01); B01L 2300/12 (2013.01); B01L 2300/1822 (2013.01); B01L 2400/082 (2013.01); G01N 2021/0389 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A flowcell device comprising:
a light source;
a flowcell body defining a flow pathway that includes a central cell;
a thermal plate in thermal contact with the flowcell body;
a Peltier device for controlling a temperature of the flowcell body via the thermal plate; and
an optical subassembly, comprising the central cell and adjacent first and second optical windows and a light source and a detector for determining an absorption spectra of a sample in the central cell via the first and second optical windows,
wherein, in the central cell, the flow pathway and a light pathway from a light source through the central cell are orthogonal to one another, and wherein the flow pathway comprises a U-shaped channel that includes the central cell.