	US 12,221,621 B2
	Support medium for 3D printing of biomaterials
Tal Dvir, Tel-Aviv (IL); and Assaf Shapira, Tel-Aviv (IL)
Assigned to Ramot at Tel-Aviv University Ltd., Tel-Aviv (IL)
Appl. No. 17/059,236
Filed by Ramot at Tel-Aviv University Ltd., Tel-Aviv (IL)
PCT Filed Jun. 4, 2019, PCT No. PCT/IL2019/050635 § 371(c)(1), (2) Date Nov. 26, 2020, PCT Pub. No. WO2019/234738, PCT Pub. Date Dec. 12, 2019.
Claims priority of provisional application 62/679,996, filed on Jun. 4, 2018.
Prior Publication US 2021/0207083 A1, Jul. 8, 2021
Int. Cl. C12N 5/00 (2006.01); A61L 27/26 (2006.01); A61L 27/36 (2006.01); A61L 27/52 (2006.01); B33Y 70/10 (2020.01); B33Y 80/00 (2015.01)

CPC C12N 5/0075 (2013.01) [A61L 27/26 (2013.01); A61L 27/3637 (2013.01); A61L 27/52 (2013.01); B33Y 70/10 (2020.01); B33Y 80/00 (2014.12); C12N 2513/00 (2013.01); C12N 2533/74 (2013.01)]

20 Claims

1. A support composition for free-form 3D printing of inks that collapse in an uncured state, comprising a plurality of hybrid hydrogel particles, said hybrid hydrogel particles comprises calcium alginate and an aqueous-soluble polymer that is not alginate, wherein said plurality of hybrid hydrogel particles is characterized by an average size that ranges from 0.1 μM to 5 μM, and homogeneity characterized by a particle size distribution of less than 20% RSD, and wherein said plurality of hybrid hydrogel particles is substantially transparent to visible light.