US 12,221,618 B2
pH-modulating biodegradable polymer and poly(glycerol sebacate)-augmented cell culture media
Peter D. Gabriele, Frisco, TX (US); Jeremy J. Harris, Doylestown, PA (US); Charles Brendan Nicholson, Coopersburg, PA (US); Steven Lu, Somerville, MA (US); and Brian Ginn, Harleysville, PA (US)
Assigned to THE SECANT GROUP, LLC, Telford, PA (US)
Filed by THE SECANT GROUP, LLC, Telford, PA (US)
Filed on Aug. 18, 2021, as Appl. No. 17/405,168.
Application 17/405,168 is a division of application No. 16/250,690, filed on Jan. 17, 2019, granted, now 11,124,762.
Claims priority of provisional application 62/624,566, filed on Jan. 31, 2018.
Claims priority of provisional application 62/618,419, filed on Jan. 17, 2018.
Prior Publication US 2021/0371811 A1, Dec. 2, 2021
Int. Cl. C12N 5/00 (2006.01); A61L 27/18 (2006.01); A61L 27/38 (2006.01); A61L 27/50 (2006.01); A61L 27/58 (2006.01); C08G 63/685 (2006.01); C08G 63/91 (2006.01); C08K 3/26 (2006.01); C08K 3/32 (2006.01); C08K 5/17 (2006.01); C08L 67/00 (2006.01)
CPC C12N 5/0018 (2013.01) [A61L 27/18 (2013.01); A61L 27/38 (2013.01); A61L 27/50 (2013.01); A61L 27/58 (2013.01); C08G 63/6854 (2013.01); C08G 63/914 (2013.01); C08K 3/26 (2013.01); C08K 3/32 (2013.01); C08K 5/175 (2013.01); C08L 67/00 (2013.01); C12N 2500/32 (2013.01); C12N 2500/50 (2013.01)] 25 Claims
 
1. A pH-modulating poly(glycerol sebacate) composition comprising poly(glycerol sebacate) and at least one pH-modulating agent covalently attached to the poly(glycerol sebacate), wherein the at least one pH-modulating agent is present in the pH-modulating poly(glycerol sebacate) composition in an amount, by weight, of about 5% or greater with respect to the weight of the pH-modulating poly(glycerol sebacate) composition.