US 12,221,611 B2
Astrocyte-specific nucleic acid aptamer and use thereof
Eun-Song Lee, Seongnam-si (KR); Miso Kim, Gyeongju-si (KR); Jin Saem Lee, Seoul (KR); Chang-Hwan Park, Seoul (KR); Young-Pil Kim, Seoul (KR); and Eun Hye Lee, Seoul (KR)
Assigned to IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY), Seoul (KR)
Appl. No. 17/285,351
Filed by IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY), Seoul (KR)
PCT Filed Oct. 15, 2019, PCT No. PCT/KR2019/013539
§ 371(c)(1), (2) Date May 11, 2021,
PCT Pub. No. WO2020/080809, PCT Pub. Date Apr. 23, 2020.
Claims priority of application No. 10-2018-0122835 (KR), filed on Oct. 15, 2018.
Prior Publication US 2021/0371864 A1, Dec. 2, 2021
Int. Cl. A61K 38/16 (2006.01); C12N 15/115 (2010.01); G01N 33/531 (2006.01); G01N 33/569 (2006.01)
CPC C12N 15/115 (2013.01) [G01N 33/56966 (2013.01); C12N 2310/16 (2013.01); C12N 2320/13 (2013.01)] 3 Claims
 
1. An aptamer capable of binding an astrocyte,
wherein the aptamer is a single strand,
wherein the aptamer consists of 80 or less nucleotides, and
wherein the aptamer comprises a polynucleotide sequence of any one of SEQ ID NOs: 1 to 10, or a fully complementary polynucleotide sequence thereof.